Calcitonin gene-related peptide 1 Antibody (FITC) is a Rabbit Polyclonal antibody against Calcitonin gene-related peptide 1 conjugated to FITC.
Calcitonin gene-related peptide, (CGRP) is a neuropeptide secreted and stored in the nervous system. In humans, CGRP exists in two forms: CGRP alpha (α-CGRP or CGRP I), a 37-amino acid neuropeptide produced through alternative splicing of the CALCA gene (CALC1) and CGRP beta (β-CGRP or CGRP II), which is encoded by a separate, nearby gene known as CALCB (CALC2). These two forms differ only by three amino acids.N-terminal disulfide bond and an amidated C-terminus and allows CGRP to bind to its receptorCGRP has a protective role in various cardiovascular diseases and its involvement in migraines has also been proven. Additionally, it has been discovered that CGRP serves as a crucial link between the nervous system and the skeletal muscle system. CGRP plays a multifaceted role by promoting osteogenesis, inhibiting bone resorption, facilitating vascular growth, and regulating the immune microenvironment.
El péptido relacionado con el gen de la calcitonina (CGRP) es un neuropéptido secretado y almacenado en el sistema nervioso. En humanos, el CGRP existe en dos formas: CGRP alfa (α-CGRP o CGRP I), un neuropéptido de 37 aminoácidos producido mediante corte y empalme alternativo del gen CALCA (CALC1) y CGRP beta (β-CGRP o CGRP II), que está codificado por un gen cercano e independiente conocido como CALCB (CALC2). Estas dos formas se diferencian sólo por tres aminoácidos. Enlace disulfuro N-terminal y un extremo C amidado que permite que el CGRP se una a su receptor. El CGRP tiene un papel protector en diversas enfermedades cardiovasculares y también se ha demostrado su implicación en las migrañas. Además, se ha descubierto que el CGRP sirve como vínculo crucial entre el sistema nervioso y el sistema del músculo esquelético. El CGRP desempeña un papel multifacético al promover la osteogénesis, inhibir la resorción ósea, facilitar el crecimiento vascular y regular el microambiente inmunológico.
Primary Antibodies
Polyclonal
Human
Calcitonin Gene Related Peptide 1 / CGRP1 (CALCA)
Rabbit
FITC
Liquid
> 95%
Purified by Protein G.
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
20 µg
50 µg
100 µg
200 µg
1 mg
Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
CALCA
No
Shipped within 5-10 working days.
NP_001029125.1, NM_001033953.2
This product is for research use only.
This product is currently in development. The lead time for this product may be several months. Please contact us at inf...
262.5€ (100 µl)
Ver másCalcitonin Protein is a recombinant Dog protein expressed in E. coli.
400€ (50 µg)
Ver másHuman Calcitonin Gene Related Peptide 1 / CGRP1 (CALCA) ELISA Kit is an ELISA Kit for the in vitro quantitative measurem...
556.25€ (96 tests)
Ver más