Cadherin, Neuronal (CDH2) Antibody
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935106861
info@markelab.com
Precio
286€ (100 µl)
Antibody anti-CDH2
proveedor
Abbexareference
abx101721Tested Applications
WB, IHC, IF/ICCreactivity
Ratstatus
RUOclonality
PolyclonalDescripción
Polyclonal Antibody to Cadherin, Neuronal (CDH2).
Background
Cadherin 2 (CDH2), also known as N-cadherin (neural cadherin), is a calcium-dependent cell adhesion molecule that belongs to the classical cadherin family. This protein is primarily expressed in neural tissue, muscle, and endothelial cells, facilitating cell-cell adhesion that is crucial for the organization and stability of various tissues, particularly during development. CDH2 mediates homophilic cell adhesion by binding to other N-cadherin molecules on neighboring cells, helping establish stable cellular contacts necessary for tissue integrity and function. Unlike CDH1, which is primarily expressed in epithelial cells, CDH2 is prevalent in mesenchymal and neural cell types and is integral to processes like embryogenesis, neural development, and wound healing. N-cadherin’s role extends beyond basic cell adhesion, as it is actively involved in signaling pathways that regulate cell migration, differentiation, and survival. In particular, CDH2 is essential during the development of the nervous system, heart, and vasculature, contributing to the morphogenesis of organs and the maintenance of neuronal connections. Additionally, CDH2 expression has significant implications in cancer progression and metastasis, particularly through the process of epithelial-mesenchymal transition (EMT), where it replaces CDH1 as cells transition to a more migratory, invasive phenotype. This behavior makes CDH2 a critical molecule not only in normal development but also in disease progression.
Características del producto
category
Primary Antibodies
clonality
Polyclonal
reactivity
Rat
immunogen target
Cadherin, Neuronal (CDH2)
host
Rabbit
conjugation
Unconjugated
form
Liquid
tested applications
WB, IHC, IF/ICC
purification
Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography.
recommended dilution
WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
size 1
100 µl
size 2
200 µl
size 3
1 ml
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
or code
CDH2
dry ice
No
availability
Shipped within 5-7 working days.
alias
Cadherin-2,CDHN,NCAD,ACOGS,ADHD8,CD325,ARVD14,CDw325,Neural cadherin,N-cadherin
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