C-type Lectin Domain Family 4 Member K (CD207) Antibody (Biotin)
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Description
Cd207 Antibody (Biotin) is a Rabbit Polyclonal against Cd207 conjugated to Biotin.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | C-type Lectin Domain Family 4 Member K (CD207) |
| Host | Rabbit |
| Reactivity | Mouse |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q8VBX4 |
| Gene ID | 246278 |
| Alias | C-type lectin domain family 4 member K,CLEC4K,Langerin |
| Background | Antibody anti-CD207 |
| Status | RUO |
Descripción
CD207, commonly referred to as langerin, is a C-type lectin receptor primarily expressed in Langerhans cells (LCs), a specialized subset of dendritic cells residing in the epidermis and other epithelial surfaces, such as the respiratory and digestive tracts. CD207 plays a critical role in immune surveillance by recognizing and binding to specific carbohydrate structures on pathogens, facilitating their capture and internalization. This receptor is crucial for pathogen recognition and uptake, which supports the initiation of adaptive immune responses. Encoded by the CD207 gene, CD207 is instrumental in the function and identity of Langerhans cells. It is also the defining marker for Langerhans cells, distinguishing them from other dendritic cell subsets. Langerhans cells use CD207 to capture and internalize pathogens, leading to antigen processing and subsequent presentation to T cells, which is central to adaptive immunity. CD207’s unique feature is its ability to induce the formation of Birbeck granules—distinctive organelles with a rod and vesicle shape that are exclusive to Langerhans cells. These granules are believed to support the specialized antigen-processing function of CD207.
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C-type Lectin Domain Family 4 Member K (CD207) Antibody
CD207 Antibody is a Rabbit Polyclonal antibody against CD207. The protein encoded by this gene is expressed only in Langerhans cells which are immature dendritic cells of the epidermis and mucosa. It is localized in the Birbeck granules, organelles present in the cytoplasm of Langerhans cells and consisting of superimposed and zippered membranes. It is a C-type lectin with mannose binding specificity, and it has been proposed that mannose binding by this protein leads to internalization of antigen into Birbeck granules and providing access to a nonclassical antigen-processing pathway. Mutations in this gene result in Birbeck granules deficiency or loss of sugar binding activity.
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