C-C Chemokine Receptor Type 4 (CCR4) Antibody
559€ (100 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
C-C Chemokine Receptor Type 4 (CCR4) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx412075
Tested Applications
ELISA, WB, IHC, FCM
Description
C-C Chemokine Receptor Type 4 (CCR4) Antibody is a Goat Polyclonal antibody against CD194.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: C-C Chemokine Receptor Type 4 (CCR4) |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 1.0 mg/ml |
| Recommended Dilution | Validated in IHC-F and IHC-P. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, FCM |
| Buffer | PBS, 0.1% BSA. Contains sodium azide. |
| Availability | Shipped within 3-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P51679 |
| Alias | CCR4,CD194,ChemR13,C-C chemokine receptor 4,CC CKR4,chemokine (C-C motif) receptor 4,CC-CKR-4 |
| Background | Antibody anti-CCR4 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
C-C Chemokine Receptor Type 4 (CCR4) is a G-protein-coupled receptor (GPCR) primarily expressed on T-helper 2 (Th2) lymphocytes, regulatory T cells (Tregs), natural killer (NK) cells, and dendritic cells. CCR4 selectively binds chemokines like CCL17 (TARC) and CCL22 (MDC), mediating immune cell migration, trafficking, and activation. It plays a significant role in directing T-cell responses during allergic inflammation and immune homeostasis. CCR4 facilitates the recruitment of Th2 cells to tissues such as the lungs, skin, and mucosal surfaces, making it a critical mediator in conditions like asthma, atopic dermatitis, and allergic rhinitis. Additionally, CCR4 is highly expressed on regulatory T cells (Tregs), which suppress immune responses and maintain tolerance, particularly in tumors, where Tregs suppress anti-tumor immunity. Elevated CCR4 expression is associated with T-cell lymphomas, including adult T-cell leukemia/lymphoma (ATLL) and cutaneous T-cell lymphoma (CTCL), where it contributes to tumor progression and immune escape. CCR4 has emerged as a therapeutic target for both autoimmune diseases and cancer. Antibodies and small-molecule antagonists targeting CCR4 are being explored to inhibit Treg recruitment in tumors, restore anti-tumor immunity, and reduce inflammation in allergic diseases. Understanding the complex interplay of CCR4 in immune responses continues to drive its role as a therapeutic target in immunotherapy and inflammatory diseases.
Productos relacionados
C-C Chemokine Receptor Type 4 (CCR4) Antibody
The protein encoded by this gene belongs to the G-protein-coupled receptor family. It is a receptor for the CC chemokine…
Ver producto
Human C-C Chemokine Receptor Type 4 (CCR4) ELISA Kit
Human C-C Chemokine Receptor Type 4 (CCR4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human …
Ver producto
Human C-C Chemokine Receptor Type 4 (CCR4) ELISA Kit
Human C-C Chemokine Receptor Type 4 (CCR4) ELISA Kit is an ELISA Kit for the in vitro quantitative measurement of Human …
Ver producto