C-C Chemokine Receptor Type 3 (CCR3) Antibody (Biotin)
169€ (20 µg)
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Name
C-C Chemokine Receptor Type 3 (CCR3) Antibody (Biotin)
Category
Primary Antibodies
Provider
Abbexa
Reference
abx300011
Tested Applications
ELISA
Description
CCR3 Antibody (Biotin) is a Rabbit Polyclonal against CCR3 conjugated to Biotin.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: C-C Chemokine Receptor Type 3 (CCR3) Immunogen: Recombinant Human C-C chemokine receptor type 3 protein (306-355AA). |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Biotin |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P51677 |
| Gene ID | 1232 |
| NCBI Accession | NP_001828.1, NM_001837.3 |
| OMIM | 601268 |
| Alias | CCR3,C C CKR3,CC-CKR-3,CD193,CKR 3,CKR3,CMKBR3,Chemokine (C-C motif) receptor 3 |
| Background | Antibody anti-CCR3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
C-C Chemokine Receptor Type 3 (CCR3) is a G-protein-coupled receptor (GPCR) that binds multiple chemokines, including CCL11 (eotaxin), CCL24 (eotaxin-2), and CCL5 (RANTES). CCR3 is predominantly expressed on eosinophils, basophils, mast cells, and Th2 lymphocytes, making it a critical regulator of allergic inflammation and immune responses. CCR3 signaling promotes eosinophil chemotaxis, activation, and survival, leading to the accumulation of eosinophils at sites of allergic inflammation, such as in asthma, allergic rhinitis, and atopic dermatitis. Additionally, CCR3 expression on retinal pigment epithelial cells and microglia links it to age-related macular degeneration (AMD) and other neuroinflammatory conditions. In parasitic infections, CCR3 plays a protective role by guiding eosinophils to sites of helminth invasion, contributing to parasite clearance. However, excessive CCR3 activation in chronic inflammation can exacerbate tissue damage and fibrosis. CCR3 is also expressed in certain cancers and may promote angiogenesis and tumor progression by recruiting pro-inflammatory cells to the tumor microenvironment. As a key mediator of allergic and inflammatory diseases, CCR3 is a promising target for therapeutic intervention. CCR3 antagonists and neutralizing antibodies are being explored for treating eosinophilic disorders, asthma, and ocular diseases, where inhibition of CCR3 can reduce eosinophil recruitment, inflammation, and tissue damage. Ongoing research into CCR3 biology continues to uncover its broader implications in inflammation, immunity, and cancer.
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