Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 (ABCG2) Antibody
416€ (200 µl)
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935106861
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name
Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 (ABCG2) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430475
tested applications
P-ELISA, WB
Description
ABCG2 Antibody is a Goat Polyclonal antibody against ABCG2.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Broad Substrate Specificity ATP-Binding Cassette Transporter ABCG2 (ABCG2) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 9429 |
| NCBI Accession | NP_004818.2, NP_001244315.1 |
| Alias | ABC15,ABCP BCRP,BCRP1 BMDP,CD338,CDw338 |
| Background | Antibody anti-ABCG2 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
ABCG2, also known as the breast cancer resistance protein (BCRP), is a well-characterized ATP-binding cassette transporter involved in drug efflux and xenobiotic clearance. It is highly expressed in barrier tissues such as the intestine, liver, kidneys, and blood-brain barrier, where it protects cells by exporting a wide range of substrates, including drugs, toxins, and endogenous metabolites. ABCG2 plays a pivotal role in pharmacokinetics, influencing drug absorption, distribution, and elimination. It is also critical in stem cell biology, where it acts as a marker for side population cells due to its role in drug resistance and dye efflux. Overexpression of ABCG2 is a major contributor to multidrug resistance in cancer, as it actively pumps chemotherapeutic agents out of tumor cells, reducing their efficacy. Structurally, ABCG2 is a half-transporter that forms functional homodimers to mediate ATP-driven substrate transport. Dysregulation of ABCG2 has been linked to diseases such as gout and certain cancers, making it a target of interest in oncology and pharmacology.
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