Breast Cancer Type 1 Susceptibility Protein Phospho-Ser1457 (BRCA1 pS1457) Antibody
52€ (10 µg)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Breast Cancer Type 1 Susceptibility Protein Phospho-Ser1457 (BRCA1 pS1457) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx012674
Tested Applications
ELISA, WB
Description
Rabbit polyclonal antibody against BRCA1 protein. Immunogen region is C-terminal. Specificity is as follows for the reactive species: H:S1457.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Breast Cancer Type 1 Susceptibility Protein Phospho-Ser1457 (BRCA1 pS1457) Immunogen: The antiserum was produced against synthesized phosphopeptide derived from human BRCA1 around the phosphorylation site of serine 1457 (L-T-SP-Q-K). |
| Host | Rabbit |
| Reactivity | Human |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/3000, ELISA: 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from rabbit antiserum by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 10 µg |
| Size 2 | 100 µg |
| Size 3 | 200 µg |
| Size 4 | 300 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | PBS (without Mg<sup>2+</sup> and Ca<sup>2+</sup>), pH 7.4, 150 mM NaCl, 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P38398 |
| Alias | BRCAI,BRCC1,BROVCA1,FANCS IRIS,PNCA4,PPP1R53,PSCP,RNF53,RING finger protein 53 |
| Background | Antibody anti-BRCA1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
BRCA1 is a tumor suppressor protein that plays a central role in maintaining genomic stability through its involvement in DNA damage repair, cell cycle regulation, and transcriptional control. BRCA1 functions as part of the homologous recombination repair pathway, where it recognizes and repairs double-strand DNA breaks, ensuring genomic integrity during cell division. It forms complexes with other DNA repair proteins, including RAD51, BARD1, and BRCA2, to facilitate accurate repair processes. BRCA1 also regulates cell cycle checkpoints, particularly at the G2/M phase, to prevent the propagation of damaged DNA. It is widely expressed in proliferative tissues, including breast and ovarian tissue, where its loss or mutation is associated with increased susceptibility to breast, ovarian, and other cancers. Mutations in BRCA1 disrupt its DNA repair function, leading to chromosomal instability, accumulation of mutations, and tumorigenesis. BRCA1 also interacts with signaling pathways involved in apoptosis, transcriptional regulation, and immune response, further highlighting its multifaceted role in cellular homeostasis. Knockout studies reveal defective DNA repair, increased tumorigenesis, and impaired cell cycle control, underscoring BRCA1’s critical function in DNA repair, tumor suppression, and genomic stability.
Productos relacionados
Breast Cancer Type 1 Susceptibility Protein Phospho-Ser1423 (BRCA1 pS1423) Antibody
BRCA1 (pS1423) Antibody is a Rabbit Polyclonal antibody against BRCA1 (pS1423). This gene encodes a nuclear phosphoprote…
Ver producto
Breast Cancer Type 1 Susceptibility Protein Phospho-Ser988 (BRCA1 pS988) Antibody
BRCA1 (pS988) Antibody is a Rabbit Polyclonal antibody against BRCA1 (pS988). This gene encodes a nuclear phosphoprotein…
Ver producto
Breast Cancer Type 1 Susceptibility Protein (BRCA1) Antibody
BRCA1 Antibody is a Rabbit Polyclonal antibody against BRCA1. This gene encodes a nuclear phosphoprotein that plays a ro…
Ver producto