Breast Cancer Anti-Estrogen Resistance Protein 1 (BCAR1) Antibody
416€ (200 µl)
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935106861
info@markelab.com
name
Breast Cancer Anti-Estrogen Resistance Protein 1 (BCAR1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx431183
tested applications
P-ELISA, WB, IHC
Description
BCAR1 Antibody is a Goat Polyclonal antibody against BCAR1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Breast Cancer Anti-Estrogen Resistance Protein 1 (BCAR1) |
| Host | Goat |
| Reactivity | Human |
| Recommended Dilution | P-ELISA: 1/128000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB, IHC |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 9564, 12927, 25414 |
| NCBI Accession | NP_001164185.1, NP_001164186.1, NP_001164187.1, NP_001164188.1, NP_001164189.1, NP_055382.2, NP_001164190.1, NP_001164191.1, NP_001164192.1 |
| Alias | BCAR1, CAS, CAS1, CASS1, CRKAS, P130Cas, Cas family scaffolding protein, Cas family scaffold protein, BCAR1 scaffold protein, Cas family member |
| Background | Antibody anti-BCAR1 |
| Status | RUO |
| Note | Concentration: 0.5 mg/ml - |
Descripción
BCAR1, also known as the Breast Cancer Anti-Estrogen Resistance 1 protein, is an important protein involved in the development of resistance to anti-estrogen therapies, such as tamoxifen, used in the treatment of estrogen receptor-positive breast cancer. BCAR1 plays a crucial role in cell signaling pathways that regulate cell survival, proliferation, and resistance to apoptosis. It is often upregulated in breast cancer cells that become resistant to estrogen receptor-targeted therapies. The protein interacts with several other signaling molecules involved in the regulation of cell motility and survival, contributing to the metastatic potential of breast cancer cells. Understanding BCAR1’s role in therapy resistance has significant implications for developing alternative therapeutic strategies for patients with estrogen receptor-positive breast cancer who develop resistance to current treatments.
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