Beta-1,3-Galactosyl-O-Glycosyl-Glycoprotein Beta-1,6-N-Acetylglucosaminyltransferase (GCNT1) Antibody

Background

Glucosaminyl (N-acetyl) transferase 1 (GCNT1) is a glycosyltransferase that catalyzes the addition of N-acetylglucosamine to mucin-type O-glycans, forming core 2 and core 4 branched structures critical for glycoprotein biosynthesis GCNT1 plays a key role in the synthesis of mucins, which protect epithelial barriers in the gastrointestinal and respiratory tracts by regulating mucus production and cell adhesion It is expressed in various tissues, particularly those with high mucus turnover, and is vital for immune responses and cellular signaling Dysregulation of GCNT1 has been associated with cancer progression, especially in breast and gastrointestinal cancers, where aberrant glycosylation promotes tumor invasion and metastasis Additionally, GCNT1 contributes to inflammatory diseases, impacting immune cell trafficking and epithelial defense pathways Studies highlight its involvement in maintaining epithelial integrity and its therapeutic potential as a target for diseases characterized by disrupted glycosylation patterns