Beta-1 Adrenergic Receptor (ADRB1) Antibody (FITC)
169€ (20 µg)
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935106861
info@markelab.com
name
Beta-1 Adrenergic Receptor (ADRB1) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx314738
Description
ADRB1 Antibody (FITC) is a Rabbit Polyclonal against ADRB1 conjugated to FITC.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Beta-1 Adrenergic Receptor (ADRB1) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P08588 |
| Gene ID | 153 |
| OMIM | 109630 |
| Alias | ADRB1,ADRB1R,Adrenergic receptor beta 1,RHR,B1AR,FNSS2,BETA1AR |
| Background | Antibody anti-ADRB1 |
| Status | RUO |
Descripción
The adrenergic receptor beta-1 (ADRB1) is a G-protein-coupled receptor that plays a critical role in cardiovascular physiology. Predominantly expressed in the heart, kidneys, and adipose tissues, ADRB1 mediates the effects of catecholamines such as epinephrine and norepinephrine. Upon activation, ADRB1 stimulates adenylate cyclase through Gs proteins, leading to increased cAMP production. This process enhances heart rate (positive chronotropy), contractility (positive inotropy), and conduction velocity (positive dromotropy), making it essential for the regulation of cardiac output. ADRB1 also influences renin secretion from the kidneys, impacting blood pressure regulation. Polymorphisms in the ADRB1 gene, such as Ser49Gly and Arg389Gly, have been linked to altered receptor activity, influencing individual responses to stress, exercise, and beta-blocker therapies. Dysregulation or overstimulation of ADRB1 is associated with conditions such as hypertension, heart failure, and arrhythmias, underscoring its significance as a therapeutic target in cardiovascular diseases.
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