Bestrophin-1 (BEST1) Antibody
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Description
Bestrophin-1 (BEST1) Antibody is a Rabbit Polyclonal antibody against Bestrophin-1 (BEST1).
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Bestrophin-1 (BEST1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | Validated in IHC-P. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by affinity chromatography using epitope-specific immunogen. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | WB, IHC |
| Buffer | PBS, pH 7.4, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O76090 |
| Gene ID | 7439 |
| Background | Antibody anti-BEST1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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BEST1 antibody
Forms calcium-sensitive chloride channels. Highly permeable to bicarbonate.
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This gene encodes a member of the bestrophin gene family. This small gene family is characterized by proteins with a highly conserved N-terminus with four to six transmembrane domains. Bestrophins may form chloride ion channels or may regulate voltage-gated L-type calcium-ion channels. Bestrophins are generally believed to form calcium-activated chloride-ion channels in epithelial cells but they have also been shown to be highly permeable to bicarbonate ion transport in retinal tissue. Mutations in this gene are responsible for juvenile-onset vitelliform macular dystrophy (VMD2), also known as Best macular dystrophy, in addition to adult-onset vitelliform macular dystrophy (AVMD) and other retinopathies. Alternative splicing results in multiple variants encoding distinct isoforms.
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