Beclin 1 (BECN1) Antibody (ATTO594)
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Description
Beclin 1 Antibody (ATTO594) is a Rabbit Polyclonal against Beclin 1.
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Beclin 1 (BECN1) |
| Host | Rabbit |
| Reactivity | Human, Rat |
| Recommended Dilution | WB: 1/1000, IF/ICC: 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | ATTO594 |
| Purification | Peptide Affinity Purified |
| Size 1 | 100 µg |
| Tested Applications | WB, IF/ICC |
| Buffer | PBS, 50% glycerol, 0.09% sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q14457 |
| Gene ID | 8678 |
| NCBI Accession | NP_001300927.1 |
| Background | Antibody anti-BECN1 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
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Beclin-1(BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.
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Beclin-1(BECN1), also known as ATG6 or VPS30, has a central role in autophagy, a process of programmed cell survival, which is increased during periods of cell stress and extinguished during the cell cycle. Beclin-1, may play a role in antiviral host defense. It protects against infection by a neurovirulent strain of Sindbis virus. Beclin-1 participates in the regulation of autophagy and has an important role in development, tumorigenesis, and neurodegeneration. A progressively reduced Beclin-1 expression is reported to correlate with the primary tumor growth of squamous cell carcinoma and adenocarcinoma of the lung. Caspase-mediated cleavage of Beclin 1 promotes crosstalk between apoptosis and autophagy.
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