BCL2-Related Protein A1 Protein

Background

BCL2 related protein A1 (BCL2A1) is an anti-apoptotic protein belonging to the Bcl-2 family, which plays a pivotal role in regulating apoptosis by inhibiting mitochondrial cell death pathways BCL2A1 functions by preventing the release of pro-apoptotic factors, such as cytochrome c, from mitochondria, thus blocking the activation of caspases and preventing cell death Its expression is often induced under stress conditions, such as oxidative stress and inflammatory stimuli, to protect cells from apoptosis BCL2A1 has been implicated in various cancers, where its overexpression allows tumor cells to evade apoptosis, promoting tumor survival and metastasis Additionally, BCL2A1 has a role in regulating immune cell function, particularly in maintaining the survival of B cells and T cells under stress Dysregulation of BCL2A1 contributes to immune system dysfunction and resistance to chemotherapy in cancer therapy, making it a potential target for therapeutic interventions aimed at promoting cell death in cancer cells