Batoclimab

Batoclimab

Pida mas información

935106861

info@markelab.com

Precio

387.5€ (100 µg)

proveedor

Abbexa

reference

abx831540

Tested Applications

ELISA, WB

reactivity

Human

status

This product is not suitable for use as medicines or in human, therapeutic or diagnostic applications (RUO

clonality

Monoclonal

Descripción

Batoclimab is a monoclonal antibody biosimilar expressed in CHO cells, targeting FCGRT, Batoclimab (HBM9161) is a fully human antibody targeting the neonatal Fc receptor (FcRn). It targets patients with neuromyelitis optica spectrum diseases and other autoimmune diseases, and can accelerate the degradation of autoantibodies in their bodies. Batoclimab (HBM9161) is an antibody that targets the neonatal Fc receptor (FcRn). FcRn expression is up-regulated by pro-inflammatory cytokines (such as TNF-α) and prolongs the half-life of IgG and serum albumin by reducing lysosomal degradation in endothelial cells and bone marrow-derived cells. Blocking the FcRn-IgG interaction can accelerate the degradation of autoantibodies and reduce the onset of various pathogenic IgG-mediated autoimmune diseases, including myasthenia gravis, thyroid ophthalmopathy, neuromyelitis optica spectrum disease and immunity Thrombocytopenia.

Características del producto

category

Biosimilars


host

Human


clonality

Monoclonal


reactivity

Human


immunogen target

FCGRT


host

Human


isotype

IgG1 Lambda


conjugation

Unconjugated


form

Liquid


tested applications

ELISA, WB


size 1

100 µg


size 2

1 mg


expression

Recombinant


purity

> 95%


purification

Purified from cell culture supernatants by Protein A/G chromatography.


buffer

0.01 M PBS. pH 7.4.


storage

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.


dry ice

No


availability

Shipped within 7-12 working days.


alias

Biosimilars


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