Batoclimab
proveedor
Abbexareference
abx831540Tested Applications
ELISA, WBreactivity
Humanstatus
This product is not suitable for use as medicines or in human, therapeutic or diagnostic applications (RUOclonality
MonoclonalDescripción
Batoclimab is a monoclonal antibody biosimilar expressed in CHO cells, targeting FCGRT, Batoclimab (HBM9161) is a fully human antibody targeting the neonatal Fc receptor (FcRn). It targets patients with neuromyelitis optica spectrum diseases and other autoimmune diseases, and can accelerate the degradation of autoantibodies in their bodies. Batoclimab (HBM9161) is an antibody that targets the neonatal Fc receptor (FcRn). FcRn expression is up-regulated by pro-inflammatory cytokines (such as TNF-α) and prolongs the half-life of IgG and serum albumin by reducing lysosomal degradation in endothelial cells and bone marrow-derived cells. Blocking the FcRn-IgG interaction can accelerate the degradation of autoantibodies and reduce the onset of various pathogenic IgG-mediated autoimmune diseases, including myasthenia gravis, thyroid ophthalmopathy, neuromyelitis optica spectrum disease and immunity Thrombocytopenia.
Características del producto
category
Biosimilars
host
Human
clonality
Monoclonal
reactivity
Human
immunogen target
FCGRT
host
Human
isotype
IgG1 Lambda
conjugation
Unconjugated
form
Liquid
tested applications
ELISA, WB
size 1
100 µg
size 2
1 mg
expression
Recombinant
purity
> 95%
purification
Purified from cell culture supernatants by Protein A/G chromatography.
buffer
0.01 M PBS. pH 7.4.
storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
dry ice
No
availability
Shipped within 7-12 working days.
alias
Biosimilars
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