Basic Leucine Zipper Transcriptional Factor ATF-Like (BATF) Antibody
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Description
BATF Antibody is a Rabbit Polyclonal against BATF.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Basic Leucine Zipper Transcriptional Factor ATF-Like (BATF) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/1000, IF/ICC: 1/10 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by immunogen affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IF/ICC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q16520 |
| Gene ID | 10538 |
| OMIM | 612476 |
| Alias | B-ATF,SF-HT-activated gene 2 protein,SFA-2 |
| Background | Antibody anti-BATF |
| Status | RUO |
| Note | Concentration: 2 mg/ml - Validity: 12 months. |
Descripción
Related Products
BATF antibody
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system: specifically mediates the differentiation of T-helper 17 cells(Th17), follicular T-helper cells(TfH), CD8(+) dendritic cells and class-switch recombination(CSR) in B-cells. Acts via the formation of a heterodimer with JUNB that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3'. The BATF-JUNB heterodimer also forms a complex with IRF4(or IRF8) in immune cells, leading to recognition of AICE sequence(5'-TGAnTCA/GAAA-3'), an immune-specific regulatory element, followed by cooperative binding of BATF and IRF4(or IRF8) and activation of genes. Controls differentiation of T-helper cells producing interleukin-17(Th17 cells) by binding to Th17-associated gene promoters: regulates expression of the transcription factor RORC itself and RORC target genes such as IL17(IL17A or IL17B). Also involved in differentiation of follicular T-helper cells(TfH) by directing expression of BCL6 and MAF. In B-cells, involved in class-switch recombination(CSR) by controlling the expression of both AICDA and of germline transcripts of the intervening heavy-chain region and constant heavy-chain region(I(H)-C(H)). Following infection, can participate in CD8(+) dendritic cell differentiation via interaction with IRF4 and IRF8 to mediate cooperative gene activation. Regulates effector CD8(+) T-cell differentiation by regulating expression of SIRT1. Following DNA damage, part of a differentiation checkpoint that limits self-renewal of hematopoietic stem cells(HSCs): up-regulated by STAT3, leading to differentiation of HSCs, thereby restricting self-renewal of HSCs(By similarity).
Ver Producto
Recombinant Human BATF
Ver Producto
Basic Leucine Zipper Transcriptional Factor ATF-Like (BATF) Antibody
Rabbit polyclonal antibody against BATF protein. Immunogen region is N-terminal.
Ver Producto