BAG Family Molecular Chaperone Regulator 3 (BAG3) Protein
234€ (2 µg)
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Name
BAG Family Molecular Chaperone Regulator 3 (BAG3) Protein
Category
Proteins and Peptides
Provider
Abbexa
Reference
abx262870
Tested Applications
SDS-PAGE
Description
BAG3 is a recombinant protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Proteins and Peptides |
| Immunogen Target | BAG3 |
| Assay Type | Activity: Not tested |
| Conjugation | Unconjugated |
| Expression | Recombinant |
| Purity | > 90% (SDS-PAGE) |
| Size 1 | 2 µg |
| Size 2 | 10 µg |
| Size 3 | 1 mg |
| Form | Liquid |
| Tested Applications | SDS-PAGE |
| Availability | Shipped within 5-10 working days. |
| Dry Ice | No |
| UniProt ID | O95817 |
| Alias | BAG-3,BIS,CAIR-1,MFM6,Bcl-2-associated athanogene 3,Bcl-2-binding protein Bis,BAG family molecular chaperone regulator 3 |
| Background | Protein BAG3 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
BAG cochaperone 3 (BAG3) is a member of the BAG family of cochaperones that interacts with heat shock proteins like HSP70 and HSP90 to regulate cellular protein folding, stress responses, and protein degradation BAG3 is essential for the proper function of the cell’s proteostasis network, contributing to the maintenance of protein quality under stress conditions It plays a significant role in the regulation of apoptosis, autophagy, and cell survival, particularly in response to oxidative stress and heat shock conditions BAG3 is involved in the stabilization of key survival proteins, making it important for promoting cell survival during cellular stress It also has a role in skeletal muscle function and heart tissue maintenance, where its dysregulation contributes to diseases such as cardiomyopathy and muscle wasting disorders BAG3 has been implicated in cancer, where its overexpression promotes tumor cell survival, resistance to chemotherapy, and metastasis Studies suggest that BAG3 influences cytoskeletal dynamics and cellular motility, making it a key factor in cell migration and tissue remodeling
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