BAG Family Molecular Chaperone Regulator 1 (BAG1) Protein

Documentos del producto

Especificaciones del producto

Proteins and Peptides

BAG1

Activity: Not tested

Unconjugated

Recombinant

> 90% (SDS-PAGE)

5 µg

20 µg

1 mg

Liquid

SDS-PAGE

Shipped within 5-10 working days.

No

Q99933

HAP,BAG-1,RAP46,Bcl-2-associated athanogene 1,BAG family molecular chaperone regulator 1

Protein BAG1

RUO

THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION.

Background

BAG cochaperone 1 (BAG1) is a cochaperone protein that interacts with heat shock proteins (HSPs) to regulate protein folding, degradation, and cellular stress responses BAG1 plays a critical role in modulating the activity of HSP70 and HSP90, chaperone proteins that assist in the proper folding and stabilization of client proteins It facilitates protein degradation by interacting with the E3 ubiquitin ligase system, ensuring the removal of misfolded or damaged proteins under cellular stress BAG1 is involved in cell survival, apoptosis, and the regulation of cell signaling, particularly in response to oxidative stress and other damaging conditions It also interacts with transcription factors and signaling molecules to influence gene expression and cellular differentiation BAG1 has been implicated in various cancers, where it promotes tumor cell survival and resistance to chemotherapy by stabilizing key oncogenic proteins Additionally, BAG1’s role in apoptosis regulation and cellular stress responses highlights its potential as a therapeutic target for diseases related to protein misfolding, cancer, and neurodegeneration