BAG Family Molecular Chaperone Regulator 1 (BAG1) Antibody
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Description
BAG1 Antibody is a Rabbit Polyclonal antibody against BAG1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | BAG Family Molecular Chaperone Regulator 1 (BAG1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q99933 |
| Gene ID | 573 |
| Alias | HAP,BAG-1,RAP46,Bcl-2-associated athanogene 1,BAG family molecular chaperone regulator 1 |
| Background | Antibody anti-BAG1 |
| Status | RUO |
Descripción
BAG cochaperone 1 (BAG1) is a cochaperone protein that interacts with heat shock proteins (HSPs) to regulate protein folding, degradation, and cellular stress responses BAG1 plays a critical role in modulating the activity of HSP70 and HSP90, chaperone proteins that assist in the proper folding and stabilization of client proteins It facilitates protein degradation by interacting with the E3 ubiquitin ligase system, ensuring the removal of misfolded or damaged proteins under cellular stress BAG1 is involved in cell survival, apoptosis, and the regulation of cell signaling, particularly in response to oxidative stress and other damaging conditions It also interacts with transcription factors and signaling molecules to influence gene expression and cellular differentiation BAG1 has been implicated in various cancers, where it promotes tumor cell survival and resistance to chemotherapy by stabilizing key oncogenic proteins Additionally, BAG1’s role in apoptosis regulation and cellular stress responses highlights its potential as a therapeutic target for diseases related to protein misfolding, cancer, and neurodegeneration
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