B-Lymphocyte Antigen CD20 (MS4A1) Antibody
292.5€ (80 µl)
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Name
B-Lymphocyte Antigen CD20 (MS4A1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx025364
Tested Applications
ELISA, WB, IHC
Description
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: B-Lymphocyte Antigen CD20 (MS4A1) Immunogen: KLH-conjugated synthetic peptide between 266-294 amino acids from the C-terminal region of human MS4A1/CD20. |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/1000, IHC-P: 1/100 - 1/1000. Not tested in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Observed MW | Calculated MW: 33.1 kDa |
| Purification | Purified Mouse Monoclonal Antibody. |
| Size 1 | 80 µl |
| Size 2 | 400 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P11836 |
| Alias | B1,S7,Bp35,CD20,FMC7,CVID5,LEU-16,B-lymphocyte antigen CD20,B-lymphocyte surface antigen B1,Leukocyte surface antigen Leu-16,Membrane-spanning 4-domains subfamily A member 1 |
| Background | Antibody anti-MS4A1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
MS4A1, also known as CD20, is a membrane-bound protein that plays a key role in the regulation of B-cell development, activation, and differentiation. It is predominantly expressed on the surface of B lymphocytes from the pre-B cell stage through to the mature B cell stage, and its expression is lost once B cells differentiate into plasma cells. CD20 is widely studied for its role in both normal immune function and its involvement in a variety of B-cell-related diseases, including non-Hodgkin lymphoma (NHL), chronic lymphocytic leukemia (CLL), and autoimmune diseases. MS4A1 is a member of the membrane-spanning 4A (MS4A) family of proteins, which includes several proteins with similar structural features, although their specific functions may differ across cell types and tissues. CD20 has become a major therapeutic target, particularly in B-cell depletion therapies, due to its restricted expression pattern and its role in the immune response. The development of anti-CD20 monoclonal antibodies, such as rituximab, has revolutionized the treatment of B-cell malignancies and certain autoimmune conditions.
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