B-Lymphocyte Antigen CD20 (MS4A1) Antibody
559€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
B-Lymphocyte Antigen CD20 (MS4A1) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx025363
Tested Applications
ELISA, WB
Description
This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This gene encodes a B-lymphocyte surface molecule which plays a role in the development and differentiation of B-cells into plasma cells. This family member is localized to 11q12, among a cluster of family members. Alternative splicing of this gene results in two transcript variants which encode the same protein. This antibody is supplied as crude ascites.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: B-Lymphocyte Antigen CD20 (MS4A1) Immunogen: KLH-conjugated synthetic peptide between 266-294 amino acids from the C-terminal region of human MS4A1/CD20. |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | WB: 1/1000 - 1/3200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Observed MW | Calculated MW: 33.1 kDa |
| Purification | Unpurified crude ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB |
| Buffer | Ascites containing 0.09% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P11836 |
| Alias | B1,S7,Bp35,CD20,FMC7,CVID5,LEU-16,B-lymphocyte antigen CD20,B-lymphocyte surface antigen B1,Leukocyte surface antigen Leu-16,Membrane-spanning 4-domains subfamily A member 1 |
| Background | Antibody anti-MS4A1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
MS4A1, also known as CD20, is a membrane-bound protein that plays a key role in the regulation of B-cell development, activation, and differentiation. It is predominantly expressed on the surface of B lymphocytes from the pre-B cell stage through to the mature B cell stage, and its expression is lost once B cells differentiate into plasma cells. CD20 is widely studied for its role in both normal immune function and its involvement in a variety of B-cell-related diseases, including non-Hodgkin lymphoma (NHL), chronic lymphocytic leukemia (CLL), and autoimmune diseases. MS4A1 is a member of the membrane-spanning 4A (MS4A) family of proteins, which includes several proteins with similar structural features, although their specific functions may differ across cell types and tissues. CD20 has become a major therapeutic target, particularly in B-cell depletion therapies, due to its restricted expression pattern and its role in the immune response. The development of anti-CD20 monoclonal antibodies, such as rituximab, has revolutionized the treatment of B-cell malignancies and certain autoimmune conditions.
Productos relacionados
B-Lymphocyte Antigen CD20 (MS4A1) Antibody
MS4A1 Antibody is a Rabbit Polyclonal antibody against MS4A1. This gene encodes a member of the membrane-spanning 4A gen…
Ver producto
B-Lymphocyte Antigen CD20 (MS4A1) Antibody
CD20 (MS4A1, membrane-spanning 4-domains, subfamily A, member 1) is a member of the membrane-spanning 4A gene family. Me…
Ver producto
B-Lymphocyte Antigen CD20 (MS4A1) Antibody
CD20 Antibody is a Mouse Monoclonal antibody against CD20.…
Ver producto