B-Cell Receptor CD22 / SIGLEC2 (CD22) Antibody (APC / Cyanine 7)
572€ (100 tests)
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935106861
info@markelab.com
name
B-Cell Receptor CD22 / SIGLEC2 (CD22) Antibody (APC / Cyanine 7)
category
Primary Antibodies
provider
Abbexa
reference
abx140983
tested applications
FCM
Description
B-Cell Receptor CD22 / SIGLEC2 (CD22) Antibody (APC / Cyanine 7) is a Mouse against B-Cell Receptor CD22 / SIGLEC2 (CD22).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | B-Cell Receptor CD22 / SIGLEC2 (CD22) |
| Host | Mouse |
| Reactivity | Human |
| Conjugation | APC / Cyanine 7 |
| Isotype | IgG1 |
| Clone ID | F305 |
| Size 1 | 100 tests |
| Tested Applications | FCM |
| Buffer | Stabilizing PBS solution containing 15 mM sodium azide. |
| Availability | Shipped within 5-12 working days. |
| Storage | Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze. |
| Dry Ice | No |
| UniProt ID | P20273 |
| Gene ID | 933 |
| Alias | SIGLEC2,SIGLEC-2,B-cell receptor CD22,B-lymphocyte cell adhesion molecule,BL-CAM,Sialic acid-binding Ig-like lectin 2,T-cell surface antigen Leu-14 |
| Background | Antibody anti-CD22 |
| Status | RUO |
Descripción
CD22, also known as Siglec-2, is a member of the sialic acid-binding immunoglobulin-like lectins (Siglec) family and is predominantly expressed on B cells. It plays a crucial role in modulating B-cell receptor (BCR) signaling and maintaining B-cell tolerance, making it an essential molecule in the regulation of the immune system. CD22 is primarily found on mature B cells, acting both as an inhibitory coreceptor to dampen BCR signaling and as an adhesion molecule involved in cell-cell interactions. CD22 is essential for maintaining the delicate balance between immune activation and tolerance, preventing excessive immune responses that could lead to autoimmune diseases. It is an inhibitory receptor that modulates B-cell activity by recruiting SHP-1, a phosphatase that negatively regulates B-cell signaling pathways. In this capacity, CD22 fine-tunes the immune response to antigens, ensuring that B cells are appropriately activated and preventing autoimmunity.
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