B-Cell Lymphoma/leukemia 10 (BCL10) Antibody
383.5€ (100 µl)
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name
B-Cell Lymphoma/leukemia 10 (BCL10) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx015774
tested applications
ELISA, WB, IHC, IF/ICC, FCM
Description
Bcl-10 (B-cell CLL/lymphoma 10), also known as CLAP, Me10, CIPER, c-E10, CARMEN.Entrez Protein NP_003912.It is a protein containing a caspase recruitment domain (CARD).It plays an important role in apoptosis and activating NF-kappaB.The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling.Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma.MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | B-Cell Lymphoma/leukemia 10 (BCL10) |
| Host | Mouse |
| Reactivity | Human, Mouse |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/200 - 1/1000, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Unpurified ascites. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Buffer | Ascitic fluid containing 0.03% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 8915 |
| Alias | CARMEN,CIPER,CLAP,IMD37,c-E10 Me10,CARD-containing molecule enhancing NF-kappa-B,CARD-like apoptotic protein, hCLAP |
| Background | Antibody anti-BCL10 |
| Status | RUO |
| Note | Concentration: Not determined. - |
Descripción
B-cell lymphoma/leukemia 10 (BCL10) is an essential signaling molecule involved in the regulation of immune cell activation, particularly in T-cell and B-cell responses BCL10 functions as a scaffolding protein in the activation of the NF-κB pathway, which is crucial for regulating inflammation, immune responses, and cell survival BCL10 forms a complex with other proteins, such as MALT1, to initiate signaling cascades that lead to immune cell activation and proliferation Its dysregulation has been linked to lymphoid malignancies, such as MALT lymphoma, where mutations or overexpression of BCL10 promote cancer cell proliferation and survival BCL10 is also involved in the regulation of apoptosis and cell differentiation, particularly in the context of immune cell maturation In addition to its role in immune cells, BCL10 has been shown to influence inflammatory diseases and autoimmunity, making it a potential target for therapeutic intervention
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