B-Cell Lymphoma/leukemia 10 (BCL10) Antibody
338€ (60 µl)
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935106861
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name
B-Cell Lymphoma/leukemia 10 (BCL10) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx001024
tested applications
WB
Description
BCL10 Antibody is a Rabbit Polyclonal antibody against BCL10. This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | B-Cell Lymphoma/leukemia 10 (BCL10) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O95999 |
| Gene ID | 8915 |
| NCBI Accession | NP_003912.1 |
| Alias | CARMEN,CIPER,CLAP,IMD37,c-E10 Me10,CARD-containing molecule enhancing NF-kappa-B,CARD-like apoptotic protein, hCLAP |
| Background | Antibody anti-BCL10 |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
B-cell lymphoma/leukemia 10 (BCL10) is an essential signaling molecule involved in the regulation of immune cell activation, particularly in T-cell and B-cell responses BCL10 functions as a scaffolding protein in the activation of the NF-κB pathway, which is crucial for regulating inflammation, immune responses, and cell survival BCL10 forms a complex with other proteins, such as MALT1, to initiate signaling cascades that lead to immune cell activation and proliferation Its dysregulation has been linked to lymphoid malignancies, such as MALT lymphoma, where mutations or overexpression of BCL10 promote cancer cell proliferation and survival BCL10 is also involved in the regulation of apoptosis and cell differentiation, particularly in the context of immune cell maturation In addition to its role in immune cells, BCL10 has been shown to influence inflammatory diseases and autoimmunity, making it a potential target for therapeutic intervention
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