B-Cell Activation Factor Receptor / BAFFR (TNFRSF13C) Antibody (FITC)
169€ (20 µg)
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935106861
info@markelab.com
name
B-Cell Activation Factor Receptor / BAFFR (TNFRSF13C) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx310261
Description
TNFRSF13C Antibody (FITC) is a Rabbit Polyclonal against TNFRSF13C conjugated to FITC.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | B-Cell Activation Factor Receptor / BAFFR (TNFRSF13C) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | FITC |
| Isotype | IgG |
| Purity | > 95% |
| Purification | Purified by Protein G. |
| Size 1 | 20 µg |
| Size 2 | 50 µg |
| Size 3 | 100 µg |
| Size 4 | 200 µg |
| Size 5 | 1 mg |
| Form | Liquid |
| Buffer | 0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q96RJ3 |
| Gene ID | 115650 |
| NCBI Accession | NP_443177.1, NM_052945.3 |
| OMIM | 606269 |
| Alias | Tumor necrosis factor receptor superfamily member 13C,BAFFR,CD268,CVID4,BAFF-R,BROMIX,prolixin,B-cell-activating factor receptor,BAFF receptor,BAFF-R |
| Background | Antibody anti-TNFRSF13C |
| Status | RUO |
Descripción
TNFRSF13C, also known as the B-cell activating factor receptor (BAFF-R), is a critical receptor involved in the regulation of B cell survival and maturation within the immune system. It belongs to the tumor necrosis factor receptor superfamily (TNFRSF), with BAFF-R specifically binding BAFF (B-cell activating factor), also known as TNFSF13B. BAFF-R signaling is essential for the differentiation of B cells and their progression through developmental stages, playing a crucial role in both innate and adaptive immunity. Dysfunction in TNFRSF13C signaling has been implicated in immune-related disorders, including autoimmune diseases and immunodeficiencies. Genetic mutations or dysregulation in BAFF-R and BAFF signaling pathways are associated with conditions such as Systemic Lupus Erythematosus (SLE) and Common Variable Immunodeficiency (CVID), as they can lead to abnormal B cell activity, autoreactivity, and altered antibody production. This receptor is also studied as a therapeutic target for autoimmune diseases, with strategies aimed at modulating BAFF levels to control B cell activity.
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