Autocrine Motility Factor Receptor (AMFR) Antibody

Este producto es parte de AMFR - E3 ubiquitin-protein ligase AMFR
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364€ (100 µg)

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935106861
info@markelab.com
name
Autocrine Motility Factor Receptor (AMFR) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx230358
tested applications
ELISA, WB, IHC, IF/ICC, IP

Description

AMFR Antibody is a Rabbit Polyclonal against AMFR.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Autocrine Motility Factor Receptor (AMFR)
Host
Rabbit
Reactivity
Human, Mouse, Rat
Recommended Dilution
WB: 1/500 - 1/5000, IHC: 1/20 - 1/200, IF/ICC: 1/10 - 1/100, IP: 1/200 - 1/2000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purity
≥ 95% (SDS-PAGE)
Purification
Purified by immunogen affinity chromatography.
Size 1
100 µg
Form
Liquid
Tested Applications
ELISA, WB, IHC, IF/ICC, IP
Buffer
PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol.
Availability
Shipped within 5-12 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
Q9UKV5
Gene ID
267
Alias
AMFR,RNF45
Background
Antibody anti-AMFR
Status
RUO
Note
Concentration: 2 mg/ml - Validity: 12 months.

Descripción

E3 ubiquitin-protein ligase AMFR, also known as autocrine motility factor receptor (AMFR), is an enzyme that plays a crucial role in the ubiquitin-proteasome system (UPS), which is responsible for the targeted degradation of proteins within cells. AMFR functions as an E3 ubiquitin ligase, which means it catalyzes the transfer of ubiquitin molecules from E2 ubiquitin-conjugating enzymes to target proteins, marking them for degradation by the proteasome. This process, known as ubiquitination, is essential for regulating various cellular processes, including protein turnover, signal transduction, and the maintenance of protein homeostasis. AMFR has been implicated in other cellular functions: Regulation of protein trafficking: AMFR is involved in the quality control of membrane proteins, particularly those destined for degradation in the endoplasmic reticulum-associated degradation (ERAD) pathway. It helps target misfolded or unassembled membrane proteins for ubiquitination and subsequent degradation by the proteasome. Regulation of cellular signaling: AMFR has been shown to interact with and regulate various signaling molecules and pathways, including the epidermal growth factor receptor (EGFR) signaling pathway

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