Atrial Natriuretic Peptide Receptor 1 (NPR1) Antibody

Product specifications

Primary Antibodies

Atrial Natriuretic Peptide Receptor 1 (NPR1)

Rabbit

Human, Mouse, Rat

ELISA: 1/1000 - 1/5000, IHC: 1/25 - 1/100. Optimal dilutions/concentrations should be determined by the end user.

Polyclonal

Unconjugated

IgG

Antigen Affinity Chromatography.

50 µl

100 µl

Liquid

ELISA, IHC

PBS, pH 7.4, containing 0.05% NaN3 and 40% Glycerol.

Shipped within 5-10 working days.

Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.

No

P16066

4881

ANPa,NPRA,ANPRA,GUC2A,GUCY2A,Guanylate cyclase A,GC-A,Atrial natriuretic peptide receptor type A

Antibody anti-NPR1

RUO

Descripción

NPR1 is a guanylate cyclase-linked receptor that binds atrial natriuretic peptide (ANP) and brain natriuretic peptide (BNP), mediating their effects on vascular homeostasis, natriuresis, and diuresis. Upon ligand binding, NPR1 undergoes conformational changes that activate its intracellular guanylyl cyclase domain, producing cyclic GMP (cGMP), a second messenger that regulates vasodilation, blood pressure, and renal salt excretion. NPR1 is primarily expressed in vascular endothelial cells, renal tubular cells, and cardiac tissue, where it plays a pivotal role in maintaining cardiovascular and renal function. Mutations or dysregulation of NPR1 are associated with hypertension, heart failure, and other cardiovascular disorders due to impaired natriuretic signaling. Structural analyses reveal that NPR1 consists of an extracellular ligand-binding domain, a transmembrane region, and an intracellular guanylyl cyclase domain, highlighting its complex regulatory mechanisms. NPR1 also interacts with protein kinases and phosphodiesterases, fine-tuning the cGMP signaling cascade. In addition to cardiovascular effects, NPR1 signaling influences adipose tissue metabolism and has been linked to lipid regulation and energy homeostasis. Emerging research suggests that NPR1 activation could be a therapeutic target for managing hypertension and heart failure by enhancing natriuretic peptide activity.

Related Products

Human NPR1 (Atrial natriuretic peptide receptor 1) ELISA Kit

Ver Producto

Recombinant Human NPR1

Ver Producto

Natriuretic Peptide Receptor A Antibody

ANPA is a receptor for atrial natriuretic peptide. It exhibits guanylate cyclase activity on binding of ANF. There seem to be at least three ANP receptors: two with guanylate cyclase activity (ANPA and ANPB) and one (ANPC) which is probably responsible for the clearance of ANP from the circulation without a role in signal transduction. This Type I membrane protein belongs to the adenylyl cyclase class-4/guanylyl cyclase family and contains 1 protein kinase-like domain.

Ver Producto