Atrial Natriuretic Peptide (ANP) Antibody
299€ (100 µl)
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935106861
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name
Atrial Natriuretic Peptide (ANP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx175522
tested applications
WB, IHC, IF/ICC
Description
Atrial Natriuretic Peptide (ANP) Antibody is a Rabbit Polyclonal antibody against Atrial Natriuretic Peptide (ANP).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Atrial Natriuretic Peptide (ANP) |
| Host | Rabbit |
| Reactivity | Dog |
| Recommended Dilution | WB: 0.01-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Purified by antigen-specific affinity chromatography, followed by Protein A affinity chromatography. |
| Size 1 | 100 µl |
| Size 2 | 200 µl |
| Size 3 | 1 ml |
| Form | Liquid |
| Tested Applications | WB, IHC, IF/ICC |
| Buffer | 0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol. |
| Availability | Shipped within 5-7 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Alias | NPPA,ANF,ANP,ATFB6,Atrial natriuretic factor |
| Background | Antibody anti-ANP |
| Status | RUO |
Descripción
Atrial Natriuretic Peptide (ANP) is a hormone secreted primarily by cardiac atrial myocytes in response to increased blood volume or pressure, playing a pivotal role in cardiovascular and fluid homeostasis. ANP exerts its effects by binding to natriuretic peptide receptor-A (NPR-A), leading to increased intracellular cyclic guanosine monophosphate (cGMP) levels, which mediate vasodilation and natriuresis. This hormone reduces systemic vascular resistance and promotes sodium and water excretion in the kidneys, thereby lowering blood pressure and blood volume. ANP is also a critical regulator of the renin-angiotensin-aldosterone system (RAAS), counteracting the effects of angiotensin II and aldosterone to prevent fluid overload. Clinically, elevated ANP levels are observed in conditions like heart failure and atrial fibrillation, serving as a biomarker for these diseases. Therapeutically, recombinant ANP and analogs are being explored for their potential in treating acute decompensated heart failure and hypertension. Research also highlights ANP’s role in protecting against cardiac hypertrophy, fibrosis, and remodeling, emphasizing its broader significance in cardiovascular health and disease management.
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