ATP-Citrate Synthase Phospho-Ser455 (ACLY pS455) Antibody

Este producto es parte de ACLY - ATP-Citrate Synthase
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221€ (50 µg)

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935106861
info@markelab.com
name
ATP-Citrate Synthase Phospho-Ser455 (ACLY pS455) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx329910
tested applications
ELISA, WB, IHC

Description

ACLY (pS455) Antibody is a Rabbit Polyclonal against ACLY (pS455).

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetATP-Citrate Synthase Phospho-Ser455 (ACLY pS455)
HostRabbit
ReactivityHuman, Mouse, Rat, Monkey
Assay DataModification: Phosphorylation // Target Modification: Ser455
Recommended DilutionELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/300. Optimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
PurificationPurified by affinity chromatography.
Size 150 µg
Size 2100 µg
FormLiquid
Tested ApplicationsELISA, WB, IHC
BufferPBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDP53396
Gene ID47
AliasACL,ATPCL,CLATP
BackgroundAntibody anti-ACLY
StatusRUO

Descripción

ATP-Citrate Synthase (ACLY) is a cytoplasmic enzyme that catalyzes the conversion of citrate and CoA into acetyl-CoA and oxaloacetate, a reaction powered by ATP hydrolysis. ACLY is a central player in cellular metabolism, linking energy production in the mitochondria with fatty acid and cholesterol biosynthesis. Acetyl-CoA generated by ACLY serves as a precursor for lipid synthesis and is essential for protein acetylation, including histone acetylation, which regulates gene expression. ACLY activity is upregulated in cancer cells to support rapid cell proliferation and metabolic reprogramming, making it a target for cancer therapy. Dysregulation of ACLY is also associated with metabolic diseases such as obesity, insulin resistance, and hyperlipidemia.
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