ATP-Citrate Synthase (ACLY) Antibody

Este producto es parte de ACLY - ATP-Citrate Synthase
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637€ (100 µl)

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935106861
info@markelab.com
name
ATP-Citrate Synthase (ACLY) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx111118
tested applications
ELISA, WB, IF/ICC

Description

Atp Citrate Lyase Antibody is a Rabbit Polyclonal antibody against Atp Citrate Lyase.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetATP-Citrate Synthase (ACLY)
HostRabbit
ReactivityHuman, Mouse, Rat
Recommended DilutionOptimal dilutions/concentrations should be determined by the end user.
ClonalityPolyclonal
ConjugationUnconjugated
IsotypeIgG
PurificationAntigen Affinity Chromatography.
Size 1100 µl
FormLiquid
Tested ApplicationsELISA, WB, IF/ICC
BufferPBS, pH 7.3, containing 0.02% Sodium Azide and 50% Glycerol.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDP53396
Gene ID47
NCBI AccessionNP_001087.2, NM_001096.2
OMIM108728
AliasACL,ATPCL,CLATP
BackgroundAntibody anti-ACLY
StatusRUO

Descripción

ATP-Citrate Synthase (ACLY) is a cytoplasmic enzyme that catalyzes the conversion of citrate and CoA into acetyl-CoA and oxaloacetate, a reaction powered by ATP hydrolysis. ACLY is a central player in cellular metabolism, linking energy production in the mitochondria with fatty acid and cholesterol biosynthesis. Acetyl-CoA generated by ACLY serves as a precursor for lipid synthesis and is essential for protein acetylation, including histone acetylation, which regulates gene expression. ACLY activity is upregulated in cancer cells to support rapid cell proliferation and metabolic reprogramming, making it a target for cancer therapy. Dysregulation of ACLY is also associated with metabolic diseases such as obesity, insulin resistance, and hyperlipidemia.
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