ATP-Citrate Synthase (ACLY) Antibody
383.5€ (100 µl)
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935106861
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name
ATP-Citrate Synthase (ACLY) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx010428
tested applications
ELISA, WB, IHC, IF/ICC, FCM
Description
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacetate from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP-Citrate Synthase (ACLY) |
| Host | Mouse |
| Reactivity | Human, Mouse, Monkey, Rat |
| Recommended Dilution | ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, IF/ICC: 1/50, FCM: 1/200 - 1/400. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Purified from ascites by Protein G chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC, IF/ICC, FCM |
| Buffer | PBS, containing 0.05% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P53396 |
| Gene ID | 47 |
| Alias | ACL,ATPCL,CLATP |
| Background | Antibody anti-ACLY |
| Status | RUO |
| Note | Concentration: 1 mg/ml - |
Descripción
ATP-Citrate Synthase (ACLY) is a cytoplasmic enzyme that catalyzes the conversion of citrate and CoA into acetyl-CoA and oxaloacetate, a reaction powered by ATP hydrolysis. ACLY is a central player in cellular metabolism, linking energy production in the mitochondria with fatty acid and cholesterol biosynthesis. Acetyl-CoA generated by ACLY serves as a precursor for lipid synthesis and is essential for protein acetylation, including histone acetylation, which regulates gene expression. ACLY activity is upregulated in cancer cells to support rapid cell proliferation and metabolic reprogramming, making it a target for cancer therapy. Dysregulation of ACLY is also associated with metabolic diseases such as obesity, insulin resistance, and hyperlipidemia.
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