ATP Citrate Lyase (ACLY) Antibody

Este producto es parte de ACLY - ATP-Citrate Synthase
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455€ (100 µl)

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935106861
info@markelab.com
name
ATP Citrate Lyase (ACLY) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx159304
tested applications
ELISA, WB, IF/ICC, FCM

Description

ACLY Antibody is a Mouse Monoclonal against ACLY.

Documents del producto

Instrucciones
Data sheet
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Product specifications

CategoryPrimary Antibodies
Immunogen TargetATP Citrate Lyase (ACLY)
HostMouse
ReactivityHuman, Mouse, Rat, Pig
Recommended DilutionWB: 1/500 - 1/5000, IF/ICC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user.
ClonalityMonoclonal
ConjugationUnconjugated
IsotypeIgG2a
PurificationAntigen Affinity Purified
Size 1100 µl
FormLiquid
Tested ApplicationsELISA, WB, IF/ICC, FCM
Buffer0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% sodium azide, 50%,glycerol.
AvailabilityShipped within 5-10 working days.
StorageAliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry IceNo
UniProt IDP53396
AliasACL,ATPCL,CLATP
BackgroundAntibody anti-ACLY
StatusRUO

Descripción

ATP-Citrate Synthase (ACLY) is a cytoplasmic enzyme that catalyzes the conversion of citrate and CoA into acetyl-CoA and oxaloacetate, a reaction powered by ATP hydrolysis. ACLY is a central player in cellular metabolism, linking energy production in the mitochondria with fatty acid and cholesterol biosynthesis. Acetyl-CoA generated by ACLY serves as a precursor for lipid synthesis and is essential for protein acetylation, including histone acetylation, which regulates gene expression. ACLY activity is upregulated in cancer cells to support rapid cell proliferation and metabolic reprogramming, making it a target for cancer therapy. Dysregulation of ACLY is also associated with metabolic diseases such as obesity, insulin resistance, and hyperlipidemia.
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