ATP Binding Cassette Transporter A3 (ABCA3) Antibody
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Description
Rabbit Polyclonal against the ABCA3 protein. This product is a carrier-free, azide-free and glycerol-free form of the
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Product specifications
| Category | Primary Antibodies |
| Immunogen Target | ATP Binding Cassette Transporter A3 (ABCA3) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB |
| Buffer | Does not contain sodium azide, carrier proteins, or glycerol. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q99758 |
| Gene ID | 21 |
| OMIM | 601615 |
| Alias | ABC-C,ABC3,LBM180,SMDP3 |
| Background | Antibody anti-ABCA3 |
| Status | RUO |
| Note | Concentration: Not applicable. - |
Descripción
ABCA3 is a critical protein in pulmonary surfactant production, predominantly expressed in alveolar type II epithelial cells in the lungs. It plays an essential role in transporting phospholipids and cholesterol into lamellar bodies, which are specialized organelles where surfactant is stored before secretion. ABCA3 utilizes ATP hydrolysis to facilitate lipid transport, ensuring the proper composition and function of surfactant, which reduces surface tension in the alveoli and prevents lung collapse. Mutations in the ABCA3 gene are associated with surfactant metabolism disorders, including neonatal respiratory distress syndrome and interstitial lung disease. These conditions are characterized by impaired surfactant production, leading to respiratory failure. ABCA3’s function in lipid transport and its critical role in pulmonary physiology underscore its importance in respiratory health.
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