ATP Binding Cassette Subfamily G Member 1 (ABCG1) Antibody (HRP)

Este producto es parte de ABCG - ATP Binding Cassette Subfamily G
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169€ (20 µg)

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935106861
info@markelab.com
name
ATP Binding Cassette Subfamily G Member 1 (ABCG1) Antibody (HRP)
category
Primary Antibodies
provider
Abbexa
reference
abx314728
tested applications
ELISA

Description

ABCG1 Antibody (HRP) is a Rabbit Polyclonal against ABCG1 conjugated to HRP.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
ATP Binding Cassette Subfamily G Member 1 (ABCG1)
Host
Rabbit
Reactivity
Human
Recommended Dilution
Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
HRP
Isotype
IgG
Purity
> 95%
Purification
Purified by Protein G.
Size 1
20 µg
Size 2
50 µg
Size 3
100 µg
Size 4
200 µg
Size 5
1 mg
Form
Liquid
Tested Applications
ELISA
Buffer
0.01 M PBS, pH 7.4, 0.03% Proclin-300 and 50% Glycerol.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid exposure to light. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P45844
Gene ID
9619
NCBI Accession
NP_004906.3, NM_004915.3
OMIM
603076
Alias
BCC7,BMFS5,LFS1,P53,TRP53,ABC8, WHITE1
Background
Antibody anti-ABCG1
Status
RUO

Descripción

ABCG1 is a transmembrane ATP-binding cassette transporter that plays a critical role in cellular cholesterol and lipid homeostasis. It is primarily involved in the efflux of cholesterol and phospholipids to high-density lipoprotein (HDL) particles, facilitating reverse cholesterol transport and preventing intracellular lipid accumulation. ABCG1 is ubiquitously expressed but is most active in macrophages, endothelial cells, and the liver, where it regulates cholesterol levels and protects cells from lipid toxicity. Structurally, ABCG1 contains nucleotide-binding domains that hydrolyze ATP to drive lipid transport across membranes. Dysregulation of ABCG1 expression has been implicated in atherosclerosis, as impaired cholesterol efflux can lead to foam cell formation in arterial walls. ABCG1 is also involved in modulating inflammation and oxidative stress, highlighting its protective role in cardiovascular health. Furthermore, ABCG1 expression is influenced by nuclear receptors such as LXR (liver X receptor), which coordinate lipid metabolism and inflammatory responses, underscoring its importance in lipid regulatory networks and metabolic diseases.

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