Aryl Hydrocarbon Receptor Interacting Protein (AIP) Antibody
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Description
AIP Antibody is a Rabbit Polyclonal against AIP.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: Aryl Hydrocarbon Receptor Interacting Protein (AIP) Immunogen: Recombinant fusion protein corresponding to human AIP |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Assay Type | Concentration: 1 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Observed MW | Calculated MW: 37 kDa Observed MW: 37 kDa |
| Purification | Purified by affinity chromatography. |
| Size 1 | 60 µl |
| Size 2 | 120 µl |
| Size 3 | 200 µl |
| Form | Liquid |
| Tested Applications | WB |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide, 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | O00170 |
| Gene ID | 9049 |
| NCBI Accession | NP_003968.3 |
| Alias | ARA9,FKBP16,FKBP37,PITA1,SMTPHN,XAP-2 |
| Background | Antibody anti-AIP |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
The Aryl-hydrocarbon-interacting protein (AIP), also known as aryl hydrocarbon receptor-interacting protein, is a cellular protein that interacts with the aryl hydrocarbon receptor (AhR). AhR is a ligand-activated transcription factor that plays a crucial role in the regulation of gene expression in response to environmental toxins, such as dioxins, polycyclic aromatic hydrocarbons (PAHs), and other xenobiotics. AIP acts as a chaperone protein for AhR, assisting in its proper folding, stabilization, and nuclear translocation upon ligand binding. Through its interaction with AhR, AIP regulates the transcriptional activity of AhR-dependent genes involved in xenobiotic metabolism, detoxification, and other cellular processes. Mutations in the AIP gene are associated with a rare hereditary condition known as familial isolated pituitary adenoma (FIPA). Individuals with FIPA develop benign tumors of the pituitary gland, which can lead to hormonal imbalances and various health issues. These mutations disrupt the normal function of AIP, impairing its ability to interact with AhR and regulate its activity effectively.
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