Aryl Hydrocarbon Receptor Interacting Protein (AIP) Antibody
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Description
Rabbit Polyclonal against the AIP protein.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Aryl Hydrocarbon Receptor Interacting Protein (AIP) |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | ELISA: 1/20000 - 1/80000, WB: 1/500 - 1/2000, IHC: 1/100 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by antigen affinity column chromatography. |
| Size 1 | 100 µg |
| Size 2 | 1 mg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | Prior to lyophilization: 1% BSA and 0.02% NaN3. |
| Availability | Shipped within 7-15 working days. |
| Storage | Store at -20 °C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| NCBI Accession | NM_003977.2 |
| Alias | ARA9,FKBP16,FKBP37,PITA1,SMTPHN,XAP-2 |
| Background | Antibody anti-AIP |
| Status | RUO |
| Note | Concentration: Lyophilized form: Not applicable. After reconstitution: 1 mg/ml. - |
Descripción
The Aryl-hydrocarbon-interacting protein (AIP), also known as aryl hydrocarbon receptor-interacting protein, is a cellular protein that interacts with the aryl hydrocarbon receptor (AhR). AhR is a ligand-activated transcription factor that plays a crucial role in the regulation of gene expression in response to environmental toxins, such as dioxins, polycyclic aromatic hydrocarbons (PAHs), and other xenobiotics. AIP acts as a chaperone protein for AhR, assisting in its proper folding, stabilization, and nuclear translocation upon ligand binding. Through its interaction with AhR, AIP regulates the transcriptional activity of AhR-dependent genes involved in xenobiotic metabolism, detoxification, and other cellular processes. Mutations in the AIP gene are associated with a rare hereditary condition known as familial isolated pituitary adenoma (FIPA). Individuals with FIPA develop benign tumors of the pituitary gland, which can lead to hormonal imbalances and various health issues. These mutations disrupt the normal function of AIP, impairing its ability to interact with AhR and regulate its activity effectively.
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