Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) Antibody

Este producto es parte de ALOX - Arachidonate lipoxygenase
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416€ (200 µl)

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935106861
info@markelab.com
name
Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430228
tested applications
P-ELISA, WB, IHC

Description

ALOX5AP Antibody is a Goat Polyclonal antibody against ALOX5AP.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Arachidonate 5-Lipoxygenase-Activating Protein (ALOX5AP)
Host
Goat
Reactivity
Human
Recommended Dilution
P-ELISA: 1/128000. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Unconjugated
Isotype
IgG
Purification
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Size 1
200 µl
Form
Liquid
Tested Applications
P-ELISA, WB, IHC
Buffer
Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin.
Availability
Shipped within 5-10 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
Gene ID
241
NCBI Accession
NP_001620.2, NP_001191335.1
Alias
ALOX5AP,FLAP
Background
Antibody anti-ALOX5AP
Status
RUO
Note
Concentration: 0.5 mg/ml - 

Descripción

Arachidonate 5-Lipoxygenase Activating Protein (ALOX5AP) is a crucial regulatory protein that facilitates the activity of 5-lipoxygenase (5-LOX), an enzyme involved in the biosynthesis of leukotrienes. Leukotrienes are lipid mediators derived from arachidonic acid that play significant roles in inflammatory and allergic responses, including bronchoconstriction, vascular permeability, and recruitment of immune cells. ALOX5AP acts as an essential cofactor, enabling 5-LOX to translocate to the nuclear membrane and interact with its substrate, leading to the production of leukotrienes. Dysregulation of ALOX5AP has been implicated in various inflammatory diseases, including asthma, atherosclerosis, and rheumatoid arthritis. Genetic variants in the ALOX5AP gene are associated with an increased risk of cardiovascular disease and stroke, making it a potential biomarker and therapeutic target. Inhibitors targeting ALOX5AP or its interaction with 5-LOX are being explored as treatments to mitigate leukotriene-mediated inflammatory conditions.

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