APPL Antibody
442€ (200 µl)
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name
APPL Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx430193
tested applications
P-ELISA, WB
Description
APPL Antibody is a Goat Polyclonal antibody against APPL.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Target: APPL Immunogen: abx269395 - C-Terminus: C-DLGEGGKKRESEA |
| Host | Goat |
| Reactivity | Human |
| Assay Type | Concentration: 0.5 mg/ml |
| Recommended Dilution | P-ELISA: 1/2000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Size 1 | 200 µl |
| Form | Liquid |
| Tested Applications | P-ELISA, WB |
| Buffer | Tris saline, pH 7.3, containing 0.02% sodium azide and 0.5% bovine serum albumin. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| Gene ID | 26060 |
| NCBI Accession | NP_036228.1 |
| Alias | APPL1, APPL, DIP13alpha, MODY14, adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 |
| Background | Antibody anti-APPL1 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Descripción
APPL1 (Phosphotyrosine Interacting with PH Domain and Leucine Zipper 1) is a protein involved in several cellular processes, particularly in intracellular signaling pathways. It is a key regulator of cellular trafficking, endocytosis, and membrane receptor recycling. APPL1 contains both a pleckstrin homology (PH) domain and a leucine zipper, which are important for its interaction with phosphotyrosine residues on target proteins. These interactions are crucial for cellular communication and the regulation of various signaling pathways that control cellular homeostasis and growth. APPL1 plays a role in the regulation of insulin signaling and is involved in the formation of signaling complexes that regulate cell survival, metabolism, and proliferation. Its role in these pathways makes it an important protein in studies related to cancer, metabolic disorders, and neurodegenerative diseases.
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