Apoptosis Regulator Bcl-2 Phospho-Thr69 (BCL2 pT69) Antibody
221€ (50 µg)
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935106861
info@markelab.com
name
Apoptosis Regulator Bcl-2 Phospho-Thr69 (BCL2 pT69) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx323126
tested applications
ELISA, IHC, IF/ICC
Description
BCL2 (pT69) Antibody is a Rabbit Polyclonal against BCL2 (pT69).
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Apoptosis Regulator Bcl-2 Phospho-Thr69 (BCL2 pT69) |
| Host | Rabbit |
| Reactivity | Human |
| Assay Data | Modification: Phosphorylation // Target Modification: Thr69 |
| Recommended Dilution | ELISA: 1/20000, IHC: 1/100 - 1/300, IF/ICC: 1/200 - 1/1000. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 50 µg |
| Size 2 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, IHC, IF/ICC |
| Buffer | PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P10415 |
| Gene ID | 596 |
| OMIM | 151430 |
| Alias | Bcl-2,PPP1R50,B-Cell CLL/Lymphoma 2 |
| Background | Antibody anti-BCL2 |
| Status | RUO |
Descripción
BCL2 apoptosis regulator (BCL2) is a key anti-apoptotic protein that plays a central role in regulating cell survival by preventing mitochondrial-mediated apoptosis BCL2 functions by inhibiting the release of pro-apoptotic factors, such as cytochrome c, from the mitochondria, thus preventing caspase activation and cell death It is highly expressed in various tissues, particularly in immune cells and neurons, where it protects against apoptosis and supports cell longevity Dysregulation of BCL2 expression has been associated with several diseases, including cancer, where its overexpression allows tumor cells to evade cell death, contributing to tumor progression and resistance to therapy BCL2 is also implicated in neurodegenerative diseases, where its dysfunction can lead to excessive neuronal death BCL2 interacts with other members of the Bcl-2 family, including pro-apoptotic proteins like BAX, to finely tune apoptotic signaling and maintain cellular homeostasis Its role in regulating apoptosis and survival pathways makes BCL2 a critical factor in development, aging, and disease management
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