Apoptosis Regulator Bcl-2 Phospho-Ser70 (BCL2 pS70) Antibody
429€ (100 µl)
Por favor contáctenos para obtener información detallada sobre el precio y disponibilidad.
Name
Apoptosis Regulator Bcl-2 Phospho-Ser70 (BCL2 pS70) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx332855
Tested Applications
ELISA, IHC
Description
BCL2 (pS70) Antibody is a Rabbit Polyclonal against BCL2 (pS70).
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Apoptosis Regulator Bcl-2 Phospho-Ser70 (BCL2 pS70) Immunogen: Peptide sequence around phosphorylation site of serine 70 (R-T-S (p)-P-L) derived from Human BCL-2. |
| Host | Rabbit |
| Reactivity | Human |
| Recommended Dilution | IHC: 1/50 - 1/100. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, IHC |
| Buffer | PBS (without Mg2+ and Ca2+), pH 7.4, containing 150mM NaCl, 0.02% sodium azide and 50% Glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P10415 |
| Gene ID | 596 |
| OMIM | 151430 |
| Alias | Bcl-2,PPP1R50,B-Cell CLL/Lymphoma 2 |
| Background | Antibody anti-BCL2 |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
BCL2 apoptosis regulator (BCL2) is a key anti-apoptotic protein that plays a central role in regulating cell survival by preventing mitochondrial-mediated apoptosis BCL2 functions by inhibiting the release of pro-apoptotic factors, such as cytochrome c, from the mitochondria, thus preventing caspase activation and cell death It is highly expressed in various tissues, particularly in immune cells and neurons, where it protects against apoptosis and supports cell longevity Dysregulation of BCL2 expression has been associated with several diseases, including cancer, where its overexpression allows tumor cells to evade cell death, contributing to tumor progression and resistance to therapy BCL2 is also implicated in neurodegenerative diseases, where its dysfunction can lead to excessive neuronal death BCL2 interacts with other members of the Bcl-2 family, including pro-apoptotic proteins like BAX, to finely tune apoptotic signaling and maintain cellular homeostasis Its role in regulating apoptosis and survival pathways makes BCL2 a critical factor in development, aging, and disease management
Productos relacionados
BCL2 (pT56) Antibody
BCL2 (pT56) Antibody is a Rabbit Polyclonal antibody against BCL2 (pT56). This gene encodes an integral outer mitochondr…
Ver producto
Apoptosis Regulator Bcl-2 (BCL2) Antibody
BCL2 Antibody is a Rabbit Polyclonal antibody against BCL2. This gene encodes an integral outer mitochondrial membrane p…
Ver producto
Apoptosis Regulator Bcl-2 (BCL2) Antibody
BCL2 Antibody is a Rabbit Polyclonal antibody against BCL2. This gene encodes an integral outer mitochondrial membrane p…
Ver producto