Apoptosis Regulator Bcl-2 (BCL2) Antibody (FITC)

Este producto es parte de BCL2 - BCL2 apoptosis regulator
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429€ (100 tests)

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935106861
info@markelab.com
name
Apoptosis Regulator Bcl-2 (BCL2) Antibody (FITC)
category
Primary Antibodies
provider
Abbexa
reference
abx139067
tested applications
FCM

Description

BCL2 Antibody is a Mouse Monoclonal against BCL2.

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Apoptosis Regulator Bcl-2 (BCL2)
Host
Mouse
Reactivity
Human
Recommended Dilution
FCM: 4 μl/100 μl of whole blood or 106 cells. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Monoclonal
Conjugation
FITC
Isotype
IgG1
Clone ID
L259
Size 1
100 tests
Tested Applications
FCM
Buffer
Stabilizing PBS solution containing 15 mM sodium azide.
Availability
Shipped within 5-12 working days.
Storage
Store in the dark at 2-8°C. Avoid exposure to light. Do not freeze.
Dry Ice
No
UniProt ID
P10415
Gene ID
596
OMIM
151430
Alias
Bcl-2,PPP1R50,B-Cell CLL/Lymphoma 2
Background
Antibody anti-BCL2
Status
RUO

Descripción

BCL2 apoptosis regulator (BCL2) is a key anti-apoptotic protein that plays a central role in regulating cell survival by preventing mitochondrial-mediated apoptosis BCL2 functions by inhibiting the release of pro-apoptotic factors, such as cytochrome c, from the mitochondria, thus preventing caspase activation and cell death It is highly expressed in various tissues, particularly in immune cells and neurons, where it protects against apoptosis and supports cell longevity Dysregulation of BCL2 expression has been associated with several diseases, including cancer, where its overexpression allows tumor cells to evade cell death, contributing to tumor progression and resistance to therapy BCL2 is also implicated in neurodegenerative diseases, where its dysfunction can lead to excessive neuronal death BCL2 interacts with other members of the Bcl-2 family, including pro-apoptotic proteins like BAX, to finely tune apoptotic signaling and maintain cellular homeostasis Its role in regulating apoptosis and survival pathways makes BCL2 a critical factor in development, aging, and disease management

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