Apoptosis Regulator Bcl-2 (BCL2) Antibody (Biotin)

Este producto es parte de BCL2 - BCL2 apoptosis regulator
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351€ (200 µl)

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935106861
info@markelab.com
name
Apoptosis Regulator Bcl-2 (BCL2) Antibody (Biotin)
category
Primary Antibodies
provider
Abbexa
reference
abx272737
tested applications
WB, IHC, IF/ICC

Description

B-Cell Leukemia/Lymphoma 2 (Bcl2) Antibody (Biotin) is a Rabbit Polyclonal antibody conjugated to Biotin against B-Cell Leukemia/Lymphoma 2 (Bcl2).

Documents del producto

Instrucciones
Data sheet
Descargar

Product specifications

Category
Primary Antibodies
Immunogen Target
Apoptosis Regulator Bcl-2 (BCL2)
Host
Rabbit
Reactivity
Mouse
Recommended Dilution
WB: 0.5-2 µg/ml, IHC: 5-20 µg/ml, IF/ICC: 5-20 µg/ml. Optimal dilutions/concentrations should be determined by the end user.
Clonality
Polyclonal
Conjugation
Biotin
Isotype
IgG
Purification
Purified by antigen-specific affinity chromatography.
Size 1
200 µl
Size 2
1 ml
Form
Liquid
Tested Applications
WB, IHC, IF/ICC
Buffer
0.01 M PBS, pH 7.4, containing 0.05% Proclin-300, 50% glycerol.
Availability
Shipped within 5-15 working days.
Storage
Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles.
Dry Ice
No
UniProt ID
P10417
Gene ID
12043
Alias
Bcl-2,PPP1R50,B-Cell CLL/Lymphoma 2
Background
Antibody anti-BCL2
Status
RUO

Descripción

BCL2 apoptosis regulator (BCL2) is a key anti-apoptotic protein that plays a central role in regulating cell survival by preventing mitochondrial-mediated apoptosis BCL2 functions by inhibiting the release of pro-apoptotic factors, such as cytochrome c, from the mitochondria, thus preventing caspase activation and cell death It is highly expressed in various tissues, particularly in immune cells and neurons, where it protects against apoptosis and supports cell longevity Dysregulation of BCL2 expression has been associated with several diseases, including cancer, where its overexpression allows tumor cells to evade cell death, contributing to tumor progression and resistance to therapy BCL2 is also implicated in neurodegenerative diseases, where its dysfunction can lead to excessive neuronal death BCL2 interacts with other members of the Bcl-2 family, including pro-apoptotic proteins like BAX, to finely tune apoptotic signaling and maintain cellular homeostasis Its role in regulating apoptosis and survival pathways makes BCL2 a critical factor in development, aging, and disease management

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