Apolipoprotein C-I (APOC1) Antibody Pair
1495€ (5 × 96 tests)
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935106861
info@markelab.com
name
Apolipoprotein C-I (APOC1) Antibody Pair
category
Antibody Pairs
provider
Abbexa
reference
abx370418
tested applications
ELISA
Description
Apolipoprotein C-I (APOC1) Antibody Pair for use in Sandwich ELISA assay development.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Antibody Pairs |
| Immunogen Target | Apolipoprotein C-I (APOC1) |
| Reactivity | Rat |
| Assay Data | Detection Antibody Biotinilated |
| Assay Type | Sandwich |
| Recommended Dilution | Dilute the Capture Antibody 125-fold with Coating Buffer. Dilute the Biotin-Conjugated Detection Antibody 200-fold with Detection Antibody Diluent. Optimal dilutions/concentrations should be determined by the end user. |
| Size 1 | 5 × 96 tests |
| Size 2 | 10 × 96 tests |
| Form | Standard: Lyophilized--Liquid (Capture Antibody and Detection Antibody) Reconstitute the standard with Standard Diluent. The volume, and therefore standard concentration, should be determined by the end user. |
| Tested Applications | ELISA |
| Buffer | The Capture and Detection Antibody both contain 0.1% sodium azide. |
| Availability | Please enquire. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P19939 |
| Gene ID | 25292 |
| Alias | APOC1, Apo-CI, ApoC-I, apo-CIB, apoC-IB, apolipoprotein C1, Apolipoprotein C-I |
| Background | Antibody Pair for APOC1 |
| Status | RUO |
| Note | This antibody pair contains ( 5 x 96 det): Detection: 50 µg Capture: 200 µg Standard: 2 µg This product is for research use only. |
Descripción
APOC1 is a small protein mainly associated with high-density lipoproteins (HDL), and to a lesser extent with very-low-density lipoproteins (VLDL) and chylomicrons. It is synthesized primarily in the liver and plays a crucial role in lipid metabolism by modulating the activity of lipoprotein lipase (LPL) and cholesteryl ester transfer protein (CETP). APOC1 inhibits CETP, thereby reducing the transfer of cholesteryl esters from HDL to LDL and VLDL, which promotes HDL cholesterol levels. It also regulates triglyceride metabolism by modulating lipolytic activity, thereby influencing plasma lipid homeostasis. Elevated APOC1 levels have been associated with dyslipidemia, atherosclerosis, and an increased risk of cardiovascular diseases. It may also play a role in inflammatory responses and has been linked to neurodegenerative diseases like Alzheimer’s disease, where it interacts with amyloid-beta peptides. Research indicates APOC1 has a protective role in the reverse cholesterol transport pathway, facilitating cholesterol efflux from peripheral tissues back to the liver. Genetic variations in the APOC1 gene influence plasma lipid profiles and susceptibility to metabolic disorders, including obesity and insulin resistance.
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