Apolipoprotein A1 (APOA1) Antibody Pair

1131€ (5 × 96 tests)
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name
Apolipoprotein A1 (APOA1) Antibody Pair
category
Antibody Pairs
provider
Abbexa
reference
abx370182
tested applications
ELISA
Description
Apolipoprotein A1 (APOA1) Antibody Pair for use in Sandwich ELISA assay development.
Documents del producto
Instrucciones
Data sheet
Product specifications
Category | Antibody Pairs |
Immunogen Target | Apolipoprotein A1 (APOA1) |
Reactivity | Human |
Assay Data | Detection Antibody Biotinilated |
Assay Type | Sandwich |
Recommended Dilution | Dilute the Capture Antibody 125-fold with Coating Buffer. Dilute the Biotin-Conjugated Detection Antibody 200-fold with Detection Antibody Diluent. Optimal dilutions/concentrations should be determined by the end user. |
Size 1 | 5 × 96 tests |
Size 2 | 10 × 96 tests |
Form | Standard: Lyophilized--Liquid (Capture Antibody and Detection Antibody) Reconstitute the standard with Standard Diluent. The volume, and therefore standard concentration, should be determined by the end user. |
Tested Applications | ELISA |
Buffer | The Capture and Detection Antibody both contain 0.1% sodium azide. |
Availability | Shipped within 5-20 working days. |
Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
Dry Ice | No |
UniProt ID | P02647 |
Gene ID | 335 |
NCBI Accession | NP_000030.1 |
OMIM | 105200 |
Alias | Apo A1,Apo-A1,apo(a), apolipoprotein A1, Apolipoprotein A-I,HPALP2,APOA1,Apolipoprotein AI |
Background | Antibody Pair for APOA1 |
Status | RUO |
Note | This antibody pair contains ( 5 x 96 det): Detection: 50 µg Capture: 200 µg Standard: 2 µg This product is for research use only. |
Descripción
APOA1 is the primary protein component of high-density lipoprotein (HDL), often referred to as "good cholesterol," where it plays a crucial role in reverse cholesterol transport. APOA1 facilitates the removal of cholesterol from peripheral tissues and delivers it to the liver for excretion via bile, thus protecting against atherosclerosis and cardiovascular disease. APOA1 is also an activator of lecithin-cholesterol acyltransferase (LCAT), an enzyme critical for HDL maturation and cholesterol esterification. Mutations in the APOA1 gene can result in familial HDL deficiency or amyloidosis, leading to cardiovascular dysfunction and systemic deposits of amyloid fibrils. As a key modulator of lipid metabolism, APOA1 is a major therapeutic target for managing dyslipidemia and reducing cardiovascular risk.
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