Apolipoprotein A1 (APOA1) Antibody
624€ (500 µg)
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935106861
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name
Apolipoprotein A1 (APOA1) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx411122
tested applications
ELISA, WB, IHC
Description
Apolipoprotein A-I (APOA1) Antibody is a Mouse Monoclonal antibody against APOLIPOPROTEIN A1.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Apolipoprotein A1 (APOA1) |
| Host | Mouse |
| Reactivity | Human |
| Recommended Dilution | Validated in IHC-F. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Purification | Purified |
| Size 1 | 500 µg |
| Form | Lyophilized |
| Tested Applications | ELISA, WB, IHC |
| Buffer | 0.01 M Sodium Phosphate, 0.01 M Sodium Borate, 0.15M Sodium Chloride |
| Availability | Shipped within 3-7 working days. |
| Storage | Store lyophilized at 2°C to 8°C. After reconstitution, aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P02647 |
| Gene ID | 335 |
| NCBI Accession | NP_000030.1 |
| OMIM | 105200 |
| Alias | Apo A1,Apo-A1,apo(a), apolipoprotein A1, Apolipoprotein A-I,HPALP2,APOA1,Apolipoprotein AI |
| Background | Antibody anti-APOA1 |
| Status | RUO |
Descripción
APOA1 is the primary protein component of high-density lipoprotein (HDL), often referred to as "good cholesterol," where it plays a crucial role in reverse cholesterol transport. APOA1 facilitates the removal of cholesterol from peripheral tissues and delivers it to the liver for excretion via bile, thus protecting against atherosclerosis and cardiovascular disease. APOA1 is also an activator of lecithin-cholesterol acyltransferase (LCAT), an enzyme critical for HDL maturation and cholesterol esterification. Mutations in the APOA1 gene can result in familial HDL deficiency or amyloidosis, leading to cardiovascular dysfunction and systemic deposits of amyloid fibrils. As a key modulator of lipid metabolism, APOA1 is a major therapeutic target for managing dyslipidemia and reducing cardiovascular risk.
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