Apolipoprotein A1 (Apo AI) Antibody
533€ (1 ml)
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935106861
info@markelab.com
name
Apolipoprotein A1 (Apo AI) Antibody
category
Primary Antibodies
provider
Abbexa
reference
abx023216
tested applications
RIA
Description
Apo AI Antibody is a Goat polyclonal antibody for lipoproteins against Apo AI.
Documents del producto
Instrucciones
Data sheet
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Apolipoprotein A1 (Apo AI) |
| Host | Goat |
| Reactivity | Mouse |
| Recommended Dilution | Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Purification | Neat. |
| Size 1 | 1 ml |
| Form | Liquid |
| Tested Applications | RIA |
| Buffer | Buffer contains NaN3 as a preservative. |
| Availability | Shipped within 10-20 working days. |
| Storage | Aliquot and store at -70°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | Q00623 |
| Gene ID | 11806 |
| Alias | Apo A1,Apo-A1,apo(a), apolipoprotein A1, Apolipoprotein A-I,HPALP2,APOA1,Apolipoprotein AI |
| Background | Antibody anti-APOA1 |
| Status | RUO |
Descripción
APOA1 is the primary protein component of high-density lipoprotein (HDL), often referred to as "good cholesterol," where it plays a crucial role in reverse cholesterol transport. APOA1 facilitates the removal of cholesterol from peripheral tissues and delivers it to the liver for excretion via bile, thus protecting against atherosclerosis and cardiovascular disease. APOA1 is also an activator of lecithin-cholesterol acyltransferase (LCAT), an enzyme critical for HDL maturation and cholesterol esterification. Mutations in the APOA1 gene can result in familial HDL deficiency or amyloidosis, leading to cardiovascular dysfunction and systemic deposits of amyloid fibrils. As a key modulator of lipid metabolism, APOA1 is a major therapeutic target for managing dyslipidemia and reducing cardiovascular risk.
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