Antithrombin-III (SERPINC1) Antibody
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Description
SERPINC1 Antibody is a Rabbit Polyclonal antibody against SERPINC1.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | Antithrombin-III (SERPINC1) |
| Host | Rabbit |
| Reactivity | Human, Mouse, Rat |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/50 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Polyclonal |
| Conjugation | Unconjugated |
| Isotype | IgG |
| Purification | Purified by affinity chromatography. |
| Size 1 | 100 µl |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, containing 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-10 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P01008 |
| Gene ID | 462 |
| Alias | AT3,AT3D,ATIII,THPH7,ATIII-R2,ATIII-T1,ATIII-T2,Antithrombin-III,Serpin C1 |
| Background | Antibody anti-SERPINC1 |
| Status | RUO |
Descripción
SERPINC1, commonly known as the gene encoding antithrombin (AT), is a critical member of the serine protease inhibitor (serpin) family. Antithrombin is primarily synthesized in the liver and secreted into the bloodstream, where it plays a vital role in regulating blood coagulation. As a serpin, its primary function is to inhibit proteases involved in coagulation, such as thrombin and factor Xa, thereby preventing excessive clot formation. Deficiencies or abnormalities in the SERPINC1 gene are closely associated with thrombotic disorders, as they lead to an increased risk of blood clots due to insufficient antithrombin activity. This deficiency can be inherited or acquired, and it plays a significant role in conditions such as deep vein thrombosis (DVT) and pulmonary embolism (PE).
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