Antigen-Presenting Glycoprotein CD1d (CD1D) Antibody
377€ (100 µg)
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Name
Antigen-Presenting Glycoprotein CD1d (CD1D) Antibody
Category
Primary Antibodies
Provider
Abbexa
Reference
abx231436
Tested Applications
ELISA, WB, IHC
Description
CD1D Antibody is a Mouse Monoclonal against CD1D.
Documentos del producto
Instrucciones
Data sheet
Especificaciones del producto
| Category | Primary Antibodies |
| Immunogen Target | Target: Antigen-Presenting Glycoprotein CD1d (CD1D) Immunogen: CD1d molecule |
| Host | Mouse |
| Reactivity | Human |
| Assay Type | Concentration: 2 mg/ml |
| Recommended Dilution | WB: 1/500 - 1/2000, IHC: 1/20 - 1/200. Optimal dilutions/concentrations should be determined by the end user. |
| Clonality | Monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Observed MW | Observed MW: 38-40 kDa |
| Purity | ≥ 95% (SDS-PAGE) |
| Purification | Purified by Protein A and Protein G affinity chromatography. |
| Size 1 | 100 µg |
| Form | Liquid |
| Tested Applications | ELISA, WB, IHC |
| Buffer | PBS, pH 7.3, with 0.02% sodium azide and 50% glycerol. |
| Availability | Shipped within 5-12 working days. |
| Storage | Aliquot and store at -20°C. Avoid repeated freeze/thaw cycles. |
| Dry Ice | No |
| UniProt ID | P15813 |
| Gene ID | 912 |
| OMIM | 188410 |
| Alias | R3,CD1A,R3G1,Antigen-presenting glycoprotein CD1d |
| Background | Antibody anti-CD1D |
| Status | RUO |
| Note | THIS PRODUCT IS FOR RESEARCH USE ONLY. NOT FOR USE IN DIAGNOSTIC, THERAPEUTIC OR COSMETIC PROCEDURES. NOT FOR HUMAN OR ANIMAL CONSUMPTION. |
Background
CD1D is a key member of the CD1 family of glycoproteins, which are specialized antigen-presenting molecules. CD1 proteins are distinct from classical major histocompatibility complex (MHC) class I and II molecules in that they present lipid and glycolipid antigens, rather than peptide antigens, to T cells. CD1D is unique within the CD1 family because of its specialized role in presenting lipid antigens to natural killer T (NKT) cells, particularly the invariant NKT (iNKT) cells, which express a semi-invariant T cell receptor (TCR). This interaction is essential for initiating rapid immune responses against a variety of pathogens, as well as in immune regulation. CD1D is expressed predominantly on antigen-presenting cells (APCs), such as dendritic cells, macrophages, and B cells, but is also found on certain epithelial cells. Through its interaction with NKT cells, CD1D mediates a range of immune responses, including the production of cytokines that regulate the function of other immune cells, such as dendritic cells, natural killer (NK) cells, and conventional T cells. This makes CD1D important not only for pathogen defense but also for the regulation of inflammation, tolerance, and tumor immunity.
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