VCL antibody
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935106861
info@markelab.com
name
VCL antibody
category
Primary Antibodies
provider
FineTest
reference
FNab09800
tested applications
ELISA, FC, IF, IHC, WB
Description
Vinculin belongs to the vinculin/alpha-catenin family. It is an actin filament(F-actin)-binding protein which involved in cell-matrix adhesion and cell-cell adhesion. Vinculin regulates cell-surface E-cadherin expression and potentiates mechanosensing by the E-cadherin complex. It may also play important roles in cell morphology and locomotion. Vinculin is a 117-kDa, 1,066-amino-acid protein which is ubiquitously expressed. Its splice variant, metavinculin(124 kDa), is muscle-specific.
Documents del producto
Product specifications
| Category | Primary Antibodies |
| Immunogen Target | vinculin (VCL) |
| Host | Mouse |
| Reactivity | Human, Rat, Mouse |
| Recommended Dilution | WB: 1:2000-1:20000; IHC: 1:50-1:500; IF: 1:50-1:500 |
| Clonality | monoclonal |
| Conjugation | Unconjugated |
| Isotype | IgG1 |
| Clone ID | 5E7 |
| Observed MW | 124 kDa |
| Purity | ≥95% as determined by SDS-PAGE |
| Purification | Protein A+G purification |
| Size 1 | 100µg |
| Form | liquid |
| Tested Applications | ELISA, FC, IF, IHC, WB |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3, -20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| UniProt ID | P18206 |
| Alias | Vinculin,Metavinculin (MV),VCL |
| Background | Antibody anti-VCL |
| Status | RUO |
| Note | Mol. Weight 124 kDa |
Descripción
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VCL antibody
Vinculin is a cytoskeletal protein associated with cell-cell and cell-matrix junctions, where it is thought to function as one of several interacting proteins involved in anchoring F-actin to the membrane. Defects in VCL are the cause of cardiomyopathy dilated type 1W. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.
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