anti- UCHL1 antibody
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935106861
info@markelab.com
name
anti- UCHL1 antibody
category
Primary Antibodies
provider
FineTest
reference
FNab09217
tested applications
ELISA, WB, IHC, IF
Descripción del producto
Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin. Also binds to free monoubiquitin and may prevent its degradation in lysosomes. The homodimer may have ATP-independent ubiquitin ligase activity.
Documents del producto
Instrucciones
Data sheet
Especificaciones del producto
| Alias | HEL-117,HEL-S-53,NDGOA,PARK5 PGP 9.5,PGP9.5,PGP95,SPG79,SPG79A,UCHL-1 Uch-L1,Neuron cytoplasmic protein 9.5,Ubiquitin thioesterase L1 |
| Background | Antibody anti-UCHL1 |
| Category | Primary Antibodies |
| Clonality | monoclonal |
| Clone ID | 1H7 |
| Conjugation | Unconjugated |
| Form | liquid |
| Gene ID | 7345 |
| Host | Mouse |
| Immunogen Target | ubiquitin carboxyl-terminal esterase L1(ubiquitin thiolesterase) |
| Isotype | IgG1 |
| Name | anti- UCHL1 antibody |
| Note | This product is for research use only. |
| Observed MW | 26 kDa |
| Provider | FineTest |
| Purification | Protein A+G purification |
| Purity | ≥95% as determined by SDS-PAGE |
| Reactivity | human,mouse,rat,pig |
| Recommended Dilution | WB: 1:5000-1:50000; IF: 1:20-1:200; IHC: 1:20-1:200 |
| Reference | FNab09217 |
| Size 1 | 100µg |
| Status | RUO |
| Storage | PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.) |
| Tested Applications | ELISA, WB, IHC, IF |
| UniProt ID | P09936 |
Descripcion del producto en español
Background en español
UCHL1 is a deubiquitinating enzyme that cleaves ubiquitin from protein substrates, playing a pivotal role in the ubiquitin-proteasome system (UPS). UCHL1 is highly expressed in neurons and is crucial for maintaining protein homeostasis, axonal transport, and synaptic function. It regulates the degradation of misfolded proteins, ensuring neuronal survival and preventing neurotoxicity. Mutations in UCHL1 are linked to neurodegenerative diseases such as Parkinson’s disease and Alzheimer’s disease due to impaired protein turnover and accumulation of toxic aggregates. It also has oncogenic and tumor-suppressive roles depending on the cellular context, regulating cell cycle progression and apoptosis. Knockout studies in mice show progressive neurodegeneration, motor dysfunction, and impaired synaptic activity, highlighting UCHL1’s critical role in neuronal maintenance, proteostasis, and neuroprotection.
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