anti- TRADD antibody

Name: anti- TRADD antibody
Brand: FineTest
SKU: FNab08915
Availability: OnlineOnly

Este producto es parte de TRADD - TNFRSF1A associated via death domain

Pida mas información

935106861

info@markelab.com

Precio

Precio a consultar

Antibody anti-TRADD

proveedor

FineTest

reference

FNab08915

Tested Applications

ELISA, WB, IHC

reactivity

human,rat

status

RUO

clonality

polyclonal

Descripción

The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A(By similarity). Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B.

Background

TNFRSF1A Associated Via Death Domain (TRADD) is an adaptor protein critical for tumor necrosis factor (TNF)-mediated signaling. It acts as a central platform for assembling signaling complexes upon TNF receptor 1 (TNFR1) activation. TRADD mediates divergent pathways leading to apoptosis, necroptosis, or NF-κB activation, depending on the recruited proteins. It plays a pivotal role in immune responses, inflammation, and cell death regulation. Aberrations in TRADD function are linked to immune dysregulation, chronic inflammation, and cancer. Its dual role in promoting cell survival and death makes it a crucial target for therapeutic strategies.

Características del producto

clonality

polyclonal

reactivity

human,rat

immunogen target

TNFRSF1A-associated via death domain

host

Rabbit

isotype

IgG

conjugation

Unconjugated

form

liquid

tested applications

ELISA, WB, IHC

observerd MW

34 kDa

purity

≥95% as determined by SDS-PAGE

purification

Immunogen affinity purified

recommended dilution

WB: 1:200 - 1:2000; IHC: 1:50 - 1:500

size 1

100µg

storage

PBS with 0.02% sodium azide and 50% glycerol pH 7.3,-20℃ for 12 months(Avoid repeated freeze / thaw cycles.)

or code

TRADD

alias

NFRSF1A associated via death domain,TRADD

uniprot id

https://www.uniprot.org/uniprotkb/Q15628

gene id

https://www.ncbi.nlm.nih.gov/gene/8717

note

This product is for research use only.

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